SECISBP2
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Official Full Name
SECIS binding protein 2 -
Overview
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. -
Synonyms
SECISBP2;SECIS binding protein 2;selenocysteine insertion sequence-binding protein 2;DKFZp686C09169;OTTHUMP00000064929;OTTHUMP00000064930;OTTHUMP00000064931;OTTHUMP00000064932;RP11 89K14.1;SBP 2;SBP2;SECISBP 2;Selenocysteine insertion sequence binding protein 2;OTTHUMP00000021618;OTTHUMP00000069896;SECIS-binding protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SECISBP2-2570H | Recombinant Human SECISBP2, GST-tagged | E.coli | Human | GST | C-term-349aa | |
| SECISBP2-5304R | Recombinant Rat SECISBP2 Protein | Mammalian Cell | Rat | His |
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| SECISBP2-1987HCL | Recombinant Human SECISBP2 293 Cell Lysate | HEK293 | Human | Non |
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| SECISBP2-4963R | Recombinant Rat SECISBP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SECISBP2-4963R-B | Recombinant Rat SECISBP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SECISBP2 involved in several pathways and played different roles in them. We selected most pathways SECISBP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SECISBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SECISBP2 has several biochemical functions, for example, mRNA 3-UTR binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SECISBP2 itself. We selected most functions SECISBP2 had, and list some proteins which have the same functions with SECISBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | POC5,PHF17,KRTAP9-4,INPP5D,KLRG1,KCNG4,SGTB,TBCB,FBXO34,ROCK1 |
| mRNA 3-UTR binding | PPP1R2P9,ELAVL1,RBM24,IGF2BP1,CPEB1A,RBM4,CARHSP1,ELAVL2,RNF40,CPEB1B |
| ribonucleoprotein complex binding | SRP54A,PIGC,PRMT5,RNF135,TIMM50,CKAP5,IFIH1,PRMT7,RNASEL,YBX2 |
| selenocysteine insertion sequence binding | NCL |
| poly(A) RNA binding | SRP72,ZC3H10,SUPT5H,LSM6,MRPS28,SUB1,RPS21,XRCC5,LLPH,HIST1H4D |
Interacting Protein
SECISBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SECISBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SECISBP2.
GOLGA2;SMAD9;PA;ATXN7L3;q9wmx2-pro_0000037548
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References
- Bubenik, JL; Miniard, AC; et al. Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2. RNA BIOLOGY 11:1402-1413(2014).
- Seeher, S; Atassi, T; et al. Secisbp2 Is Essential for Embryonic Development and Enhances Selenoprotein Expression. ANTIOXIDANTS & REDOX SIGNALING 21:835-849(2014).
