SEC14L2
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Official Full Name
SEC14-like 2 (S. cerevisiae) -
Overview
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
SEC14L2;SEC14-like 2 (S. cerevisiae);C22orf6, SEC14 (S. cerevisiae) like 2;SEC14-like protein 2;KIAA1186;KIAA1658;SPF;supernatant protein factor;TAP;Alpha tocopherol associated protein;Alpha-tocopherol-associated protein;C22orf6;hTAP;MGC65053;OTTHUMP00000198972;OTTHUMP00000198973;OTTHUMP00000198974;OTTHUMP00000199021;S14L2_HUMAN;SEC14 (S. cerevisiae) like 2;SEC14 like 2 (S. cerevisiae);SEC14 like protein 2;Squalene transfer protein;TAP1;tocopherol-associated protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SEC14L2-89H | Recombinant Human SEC14L2 protein, His-tagged | E.coli | Human | His | 419aa(including fusion tag) |
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| SEC14L2-1998HCL | Recombinant Human SEC14L2 293 Cell Lysate | HEK293 | Human | Non |
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| SEC14L2-4273H | Recombinant Human SEC14L2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Sec14l2-5741M | Recombinant Mouse Sec14l2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
SEC14L2 involved in several pathways and played different roles in them. We selected most pathways SEC14L2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC14L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SEC14L2 has several biochemical functions, for example, enzyme activator activity,phospholipid binding,transferase activity, transferring alkyl or aryl (other than methyl) groups. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC14L2 itself. We selected most functions SEC14L2 had, and list some proteins which have the same functions with SEC14L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | ALDH1A2,RICTOR,PSAPL1,GM1679,PSAP,ARL1,PRKCD,GTF3C4,CLPSL1,SLX4 |
| vitamin E binding | TTPA,AFM |
| phospholipid binding | ABCA1,SPTBN2,APOA5,PACSIN1,LRBA,MYOF,PLA2G2A,NBEAA,PLA2G15,SPTBN1 |
| transporter activity | CHP,APODA.1,SLCO4C1,SYPA,ATP5O,SLC25A38B,NUP155,SLCO1F4,SLC37A4,SLCO1A6 |
Interacting Protein
SEC14L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC14L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC14L2.
Ppm1l
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References
- Zingg, JM; Libinaki, R; et al. Modulation of Phosphorylation of Tocopherol and Phosphatidylinositol by hTAP1/SEC14L2-Mediated Lipid Exchange. PLOS ONE 9:-(2014).
- Zingg, JM; Azzi, A; et al. Induction of VEGF Expression by Alpha-Tocopherol and Alpha-Tocopheryl Phosphate via PI3K gamma/PKB and hTAP1/SEC14L2-Mediated Lipid Exchange. JOURNAL OF CELLULAR BIOCHEMISTRY 116:398-407(2015).
