SDHD
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Official Full Name
succinate dehydrogenase complex, subunit D, integral membrane protein -
Overview
Succinate dehydrogenase complex subunit D (SDHD) is a member of the CybS family and is one of four subunits of the succinate dehydrogenase (SDH) complex involved in the electron transport chain of the mitochondria. The specific role of SDH is to transfer electrons from succinate to ubiquinone, and the SDHD subunit is involved in anchoring the SDH complex to the inner mitochondrial membrane. Defective SDHD has been linked to Carney-Stratakis syndrome, a condition characterized by concurrent paraganglioma and gastric stromal sarcomas. -
Synonyms
SDHD;succinate dehydrogenase complex, subunit D, integral membrane protein;PGL, PGL1;succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial;QPs3;cybS;CII-4;succinate-ubiquinone reductase membrane anchor subunit;succinate-ubiquinone oxidoreductase cytochrome b small subunit;PGL;CBT1;PGL1;SDH4
Recombinant Proteins
- Chicken
- Mouse
- Human
- Rhesus macaque
- Rat
- Drosophila melanogaster (Fruit fly)
- Rickettsia bellii
- Shigella flexneri
- Pongo Abelii
- Rickettsia felis
- Mus musculus
- Sheep
- Rickettsia conorii
- Bovine
- E.coli
- Rickettsia prowazekii
- Paracoccus denitrificans
- Rickettsia typhi
- Sus scrofa (Pig)
- Halobacterium Salinarum
- Coxiella Burnetii
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
SDHD involved in several pathways and played different roles in them. We selected most pathways SDHD participated on our site, such as Citrate cycle (TCA cycle),Oxidative phosphorylation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | CREB3L1,VDAC1,BAX,ATP5O,NDUFV2,NDUFA10,NDUFC2,Casp3,IFT57,NDUFA8 |
| Alzheimers disease | APBB1,CAPN1,NDUFS4,UQCRFS1,CALM3,CALML5,GRIN2A,NDUFA3,FADD,Casp3 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFC2-KCTD14,UQCRH,PRKAA1,TNFRSF1A,ADIPOR2,UQCRB,SDHC,COX7B2,ITCH,PIK3R5 |
| Oxidative phosphorylation | ATP6V1D,NDUFS8A,UQCRH,UQCRC1,NDUFB4,NDUFS2,ATP5F1,ATP6V1G3,COX10,ATP5G3B |
| Citrate cycle (TCA cycle) | SUCLG2,IDH1,FH,SDHC,SUCLA2,PDHA1B,OGDHL,DLAT,DLST,SUCLG1 |
| Parkinsons disease | Atp5g2,UQCRC2,MT-ND1,SLC25A5,NDUFB11,NDUFA8,NDUFB8,MT-ND4,GNAI2,SDHC |
| Carbon metabolism | ACAT1,GPI,GOT2A,ACADM,PDHA1A,ENO3,FBP1A,SDS,GLUD1,PGK2 |
| Metabolic pathways | ACOX3,PLA2G10,CKMT1,AK9,ETNPPL,PI4KA,FUT9A,PPAP2CB,GFPT2,GALNT2 |
Protein Function
SDHD has several biochemical functions, for example, electron carrier activity,heme binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHD itself. We selected most functions SDHD had, and list some proteins which have the same functions with SDHD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZFP932,ZNF285A,GIT2B,SMPD3,ANTXR2,CAPN8,ADNPA,THAP7,ZNF785,ZFP654 |
| heme binding | CYP2C50,CYP3C4,MB,HBQ1,SDHDB,CYP2X9,HBAD,CYP2C9,HBB-B2,HBG1 |
| electron carrier activity | AOX3L1,GLDC,ACAD9,AKR1A1,FDX1B,PTGES2,UQCR11,PHGDH,NDUFS6,CYP1A2 |
| ubiquinone binding | SDHB,SDHDB,DHODH,ETFDH,SDHDA |
| succinate dehydrogenase activity | SDHA |
Interacting Protein
SDHD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHD here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHD.
SLC25A5
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References
- Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).
- Pai, R; Manipadam, MT; et al. Usefulness of Succinate dehydrogenase B (SDHB) immunohistochemistry in guiding mutational screening among patients with pheochromocytoma-paraganglioma syndromes. APMIS 122:1130-1135(2014).
