SCYL1

  • Official Full Name

    SCY1-like 1 (S. cerevisiae)

  • Overview

    This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SCYL1;SCY1-like 1 (S. cerevisiae);N terminal kinase like , NTKL;N-terminal kinase-like protein;GKLP;HT019;MGC78454;NKTL;P105;TAPK;TEIF;telomerase regulation associated protein;telomerase transcriptional elements interacting factor;teratoma associated tyrosine kinase;TRAP;Coated vesicle associated kinase of 90 kDa;CVAK90;Likely ortholog of mouse N terminal kinase like protein;N terminal kinase like;N terminal kinase like protein;NTKL;NTKLBP1;SCY L1;SCY1 like 1;SCY1 like 1 protein 1;SCYL 1;SCYL1BP1;Telomerase transcriptional element interacting factor;SCY1-like protein 1;teratoma-associated tyrosine kinase;telomerase regulation-associated protein;coated vesicle-associated kinase of 90 kDa;telomerase transcriptional element-interacting factor;telomerase transcriptional ele

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    SCYL1 involved in several pathways and played different roles in them. We selected most pathways SCYL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SCYL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    SCYL1 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCYL1 itself. We selected most functions SCYL1 had, and list some proteins which have the same functions with SCYL1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SCYL2,DDX54,SBK1,BTK,CSNK1G2A,GRK5,TTLL9,IQCA1,PL10,CDK7
    protein kinase activity NEK1,TNIKB,PRPF4B,STK24A,CAMK2D1,PDK4,EPHA2A,PTK2,PRKACAB,CDK5R1
    protein binding IL1RL1,GJD3,KLF15,BLOC1S3,RAB13,RNF168,KCNQ5,TOE1,PHOSPHO2-KLHL23,DENR

    Interacting Protein

    SCYL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCYL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCYL1.

    Resources

    References

    • Schmidt, WM; Kraus, C; et al. Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration. EMBO REPORTS 8:691-697(2007).

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