SCT
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Official Full Name
secretin -
Overview
Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. -
Synonyms
SCT;secretin;OTTHUMP00000164437
Recombinant Proteins
- Mouse
- Chicken
- Human
- Rat
- E.coli
- Mammalian Cell
- Synthetic
- HEK293
- HEK293T
- His&T7
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Sct-1476M | Recombinant Mouse Sct protein, His & T7-tagged | E.coli | Mouse | His&T7 | Pro26~Arg133 |
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| SCT-14781M | Recombinant Mouse SCT Protein | Mammalian Cell | Mouse | His |
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| SCT-2203C | Recombinant Chicken SCT | Mammalian Cell | Chicken | His |
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| SCT-347H | Recombinant Human Secretin | Synthetic | Human | Non |
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| SCT-5280R | Recombinant Rat SCT Protein | Mammalian Cell | Rat | His |
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| SCT-2019HCL | Recombinant Human SCT 293 Cell Lysate | HEK293 | Human | Non |
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| SCT-4939R | Recombinant Rat SCT Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCT-4939R-B | Recombinant Rat SCT Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Sct-5725M | Recombinant Mouse Sct Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SCT-58H | Secretin Reference standard | Human | Non |
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| SCT-7952M | Recombinant Mouse SCT Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCT-7952M-B | Recombinant Mouse SCT Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCT involved in several pathways and played different roles in them. We selected most pathways SCT participated on our site, such as Class B/2 (Secretin family receptors),G alpha (s) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | PROK1,LPAR2B,RLN3A,SST1.1,VIP2,GNA13B,SSTR2,GCGB,CXCL13,NMUR1 |
| Class B/2 (Secretin family receptors) | RAMP2,RAMP1,ADCYAP1B,EMR2,RCA2.1,PTH2,ADM2,GHRH,ADM,PTHLH |
| G alpha (s) signalling events | DRD5,GHRH,ADRB3,NPS,PTHLHA,VIP2,GCGB,ADCYAP1,CALCRL,RLN3 |
| Signal Transduction | C,STARD13,FSTL1A,ARHGAP11A,OTUD7B,MYO7AA,RBP4,GPR18,CCBP2,GPR68 |
| Signaling by GPCR | OPN1LW1,GPR120,FGD2,PENK,PTH2,OPN5,ADM2A,OPN4A,PTHRP2,ZFPM2B |
| GPCR ligand binding | PNOCB,GNB5A,SSTR2,GPR18,CCR3,CXCL13,KEL,OXGR1A.3,PROKR2,ADM2A |
Protein Function
SCT has several biochemical functions, for example, hormone activity,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCT itself. We selected most functions SCT had, and list some proteins which have the same functions with SCT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | RLN3A,SST2,GH2,Retnla,PPY,PRL6A1,PRL8A8,IFNT2,CGA,PTHLHA |
| protein N-terminus binding | FEZ1,TSC1,ACTN4,PEX14,RELA,MNAT1,SMARCA4,GTF2H2,TGFB1,LACRT |
Interacting Protein
SCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCT here. Most of them are supplied by our site. Hope this information will be useful for your research of SCT.
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References
- Schuster, FR; Stanglmaier, M; et al. Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. BRITISH JOURNAL OF HAEMATOLOGY 169:90-102(2015).
