SCRIB
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Official Full Name
scribbled homolog (Drosophila) -
Overview
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. -
Synonyms
SCRIB;scribbled homolog (Drosophila);protein scribble homolog;KIAA0147;SCRB1;Vartul;CRIB1;SCRIB1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCRIB-14775M | Recombinant Mouse SCRIB Protein | Mammalian Cell | Mouse | His |
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| SCRIB-1657Z | Recombinant Zebrafish SCRIB | Mammalian Cell | Zebrafish | His |
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| SCRIB-01HL | Recombinant Human SCRIB Protein, Myc/DDK-tagged | HEK293T | Human | Myc&DDK |
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| SCRIB-7947M | Recombinant Mouse SCRIB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCRIB-7947M-B | Recombinant Mouse SCRIB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCRIB involved in several pathways and played different roles in them. We selected most pathways SCRIB participated on our site, such as Hippo signaling pathway,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCRIB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | NFKB2,ATP6V0D1,CREB3L1,TBP,GTF2H4,HLA-F,ACTN2,GTF2B,HIST1H4L,HPN |
| Hippo signaling pathway | BMP6,CDH1,BMP8A,BMP2,PARD6A,PARD3,WNT4,AREG,ID1,WWTR1 |
Protein Function
SCRIB has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCRIB itself. We selected most functions SCRIB had, and list some proteins which have the same functions with SCRIB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IRS1,CIC,RALGAPA1,TRAF7,PDIA2,PLRG1,MRPL45,ROCK2,PRPF31,EGR1 |
Interacting Protein
SCRIB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCRIB here. Most of them are supplied by our site. Hope this information will be useful for your research of SCRIB.
Crtam;PHLPP1;PHLPP2;Ywhae;Tmem173;Prkcd;Cdc42
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References
- Nguyen, MM; Rivera, C; et al. Localization of PDZ domain containing proteins discs large-1 and scribble in the mouse eye. MOLECULAR VISION 11:1183-1199(2005).
