SCNN1G
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Official Full Name
sodium channel, non-voltage-gated 1, gamma subunit -
Overview
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009] -
Synonyms
SCNN1G;sodium channel, non-voltage-gated 1, gamma subunit;PHA1;BESC3;ENaCg;SCNEG;ENaCgamma;amiloride-sensitive sodium channel subunit gamma;gamma-ENaC;gamma-NaCH;ENaC gamma subunit;epithelial Na(+) channel subunit gamma;sodium channel, nonvoltage-gated 1, gamma;nonvoltage-gated sodium channel 1 subunit gamma;amiloride-sensitive sodium channel gamma-subunit;amiloride-sensitive epithelial sodium channel gamma subunit
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCNN1G-2539H | Recombinant Human SCNN1G protein, His-tagged | E.coli | Human | His | Thr80~Thr401 | |
| SCNN1G-14768M | Recombinant Mouse SCNN1G Protein | Mammalian Cell | Mouse | His |
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| SCNN1G-3417H | Recombinant Human SCNN1G, His-tagged | E.Coli or Yeast | Human | His | 649 |
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| Scnn1g-3418R | Recombinant Rat Scnn1g, His-tagged | E.Coli or Yeast | Rat | His | 650 |
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| SCNN1G-5273R | Recombinant Rat SCNN1G Protein | Mammalian Cell | Rat | His |
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| SCNN1G-1570HCL | Recombinant Human SCNN1G cell lysate | Human | Non |
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| SCNN1G-300H | Recombinant Human SCNN1G protein, His-tagged | E.coli | Human | His | Met1~Val182 |
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| SCNN1G-4932R | Recombinant Rat SCNN1G Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCNN1G-4932R-B | Recombinant Rat SCNN1G Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SCNN1G-7940M | Recombinant Mouse SCNN1G Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCNN1G-7940M-B | Recombinant Mouse SCNN1G Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCNN1G involved in several pathways and played different roles in them. We selected most pathways SCNN1G participated on our site, such as Taste transduction,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCNN1G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Taste transduction | TAS1R2,TAS2R106,GNB3,TAS2R138,TAS2R140,TAS2R117,GNAS,TAS2R16,GRM4,TAS2R144 |
| Aldosterone-regulated sodium reabsorption | ATP1A3,ATP1B4,IGF1,ATP1B3,SFN,PIK3CG,KRAS,PIK3CD,MAPK3,NR3C2 |
Protein Function
SCNN1G has several biochemical functions, for example, WW domain binding,ion channel activity,contributes_to ligand-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCNN1G itself. We selected most functions SCNN1G had, and list some proteins which have the same functions with SCNN1G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| WW domain binding | FAM189B,SHISA5,TCEAL8,PMEPA1,TCEAL7,KIF20B,LITAF,TRAF4,PPARG,NFE2 |
| protein binding | ZC3H10,BUD13,MAX,MYO7B,TINAGL1,IGSF8,PIGK,TLE2,GNA12,ACOT8 |
| sodium channel activity | SCN4AB,SCN1LAB,ASIC3,SCN11A,TRPM5,ASIC4,TRPM2,SLC4A11,SCN8AA,ASIC4A |
| contributes_to ligand-gated sodium channel activity | SCNN1B,SCNN1A |
| ion channel activity | SCN8AA,KCNG4A,P2RX3B,FXYD5,Chrng,GRIN2A,FXYD7,ITPR1,GJD3,NALCN |
Interacting Protein
SCNN1G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCNN1G here. Most of them are supplied by our site. Hope this information will be useful for your research of SCNN1G.
COMMD1;NEDD4
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References
- Yang, KQ; Lu, CX; et al. A novel frameshift mutation of epithelial sodium channel beta-subunit leads to Liddle syndrome in an isolated case. CLINICAL ENDOCRINOLOGY 82:611-614(2015).
- Yang, XL; He, J; et al. Associations of Epithelial Sodium Channel Genes With Blood Pressure Changes and Hypertension Incidence: The GenSalt Study. AMERICAN JOURNAL OF HYPERTENSION 27:1370-1376(2014).
