SCNN1A
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Official Full Name
sodium channel, non-voltage-gated 1 alpha subunit -
Overview
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many;organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes;the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare;salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced;transcript variants encoding different isoforms have been described for this gene. -
Synonyms
SCNN1A;sodium channel, non-voltage-gated 1 alpha subunit;SCNN1, sodium channel, non voltage gated 1 alpha , sodium channel, nonvoltage gated 1 alpha;amiloride-sensitive sodium channel subunit alpha;ENaCalpha;alpha-ENaC;alpha-NaCH;alpha ENaC-2;ep
Recombinant Proteins
- Bovine
- Rat
- Chicken
- Human
- Mouse
- E.Coli or Yeast
- Mammalian Cell
- E.coli
- HEK293
- His
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCNN1A-3411B | Recombinant Bovine SCNN1A, His-tagged | E.Coli or Yeast | Bovine | His | 650 |
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| Scnn1a-3412R | Recombinant Rat Scnn1a, His-tagged | E.Coli or Yeast | Rat | His | 698 |
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| SCNN1A-5271R | Recombinant Rat SCNN1A Protein | Mammalian Cell | Rat | His |
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| SCNN1A-6702C | Recombinant Chicken SCNN1A | Mammalian Cell | Chicken | His |
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| SCNN1A-7976H | Recombinant Human SCNN1A protein, His & T7-tagged | E.coli | Human | His&T7 | Tyr112~Thr543 |
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| Scnn1a-7977M | Recombinant Mouse Scnn1a protein, His & T7-tagged | E.coli | Mouse | His&T7 | Thr156~Ser518 |
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| SCNN1A-4930R | Recombinant Rat SCNN1A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCNN1A-4930R-B | Recombinant Rat SCNN1A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SCNN1A-6242H | Recombinant Human SCNN1A Protein (Tyr112-Thr543), N-His tagged | E.coli | Human | His | Tyr112-Thr543 |
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Involved Pathway
SCNN1A involved in several pathways and played different roles in them. We selected most pathways SCNN1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SCNN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SCNN1A has several biochemical functions, for example, contributes_to ligand-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCNN1A itself. We selected most functions SCNN1A had, and list some proteins which have the same functions with SCNN1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ligand-gated sodium channel activity | SCNN1B,SCNN1G |
Interacting Protein
SCNN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCNN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCNN1A.
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References
- Friso, S; Carvajal, CA; et al. Epigenetics and arterial hypertension: the challenge of emerging evidence. TRANSLATIONAL RESEARCH 165:154-165(2015).
- Zhang, ZZ; Chen, J; et al. miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene. ARCHIVES OF VIROLOGY 159:3335-3343(2014).
