SCN8A
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Official Full Name
sodium channel, voltage gated, type VIII, alpha subunit -
Overview
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore;region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that;occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with;mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript;variants.
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCN8A-2751H | Recombinant Human SCN8A protein, His-tagged | E.coli | Human | His | 1767 - 1907 aa | |
| SCN8A-5269R | Recombinant Rat SCN8A Protein | Mammalian Cell | Rat | His |
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| SCN8A-301483H | Recombinant Human SCN8A protein, GST-tagged | E.coli | Human | GST | Met1767-Glu1907 |
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| SCN8A-4928R | Recombinant Rat SCN8A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCN8A-4928R-B | Recombinant Rat SCN8A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SCN8A involved in several pathways and played different roles in them. We selected most pathways SCN8A participated on our site, such as Axon guidance,Developmental Biology,Interaction between L1 and Ankyrins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| L1CAM interactions | SCN2A,NRP2,SCN9A,RANBP9,NRP1A,KCNQ3,SCN4A,KCNQ2,DPYSL2,DLG3 |
| Developmental Biology | NRG2A,FGF18B,COL6A3,FGF10B,PHB,EFNB1,LIN28A,PAK4,GDNF,EPHB3A |
| Interaction between L1 and Ankyrins | SCN3B,SCN2B,KCNQ3,NADL1.1,ANK2B,SCN2A,SCN4A,SCN9A,KCNQ2,SCN3A |
| Axon guidance | KBTBD7,NTN1A,COL9A1,FGFR1B,COL6A3,RHOAE,SPRED3,LIMK2,NETO2,PITPNA |
Protein Function
SCN8A has several biochemical functions, for example, ATP binding,voltage-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN8A itself. We selected most functions SCN8A had, and list some proteins which have the same functions with SCN8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated sodium channel activity | ASIC4A,SCN1BB,SCN3A,SCN1A,HCN2,SCN1LAB,SCN4AA,SCN12AB,HCN4,SCN9A |
| ATP binding | MAK,CHD1,ERN2,NLRP9B,DNAJA1,SMG1,ACTB2,BMPR2A,NME2B.1,UBE2A |
Interacting Protein
SCN8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN8A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN8A.
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