SCIN
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Official Full Name
scinderin -
Overview
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 (PubMed 11568009)). -
Synonyms
SCIN;scinderin;adseverin;KIAA1905
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCIN-2533H | Recombinant Human SCIN, GST-tagged | E.coli | Human | GST | N-term-357aa | |
| SCIN-14748M | Recombinant Mouse SCIN Protein | Mammalian Cell | Mouse | His |
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| SCIN-4160Z | Recombinant Zebrafish SCIN | Mammalian Cell | Zebrafish | His |
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| SCIN-4517C | Recombinant Chicken SCIN | Mammalian Cell | Chicken | His |
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| SCIN-1568HCL | Recombinant Human SCIN cell lysate | Human | Non |
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| SCIN-1445H | Recombinant Human SCIN Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Scin-5714M | Recombinant Mouse Scin Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SCIN-7933M | Recombinant Mouse SCIN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCIN-7933M-B | Recombinant Mouse SCIN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCIN involved in several pathways and played different roles in them. We selected most pathways SCIN participated on our site, such as Fc gamma R-mediated phagocytosis,Regulation of actin cytoskeleton,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | PLCG2,WAS,PLA2G4F,PIK3R1,MAPK1,PRKCG,ASAP1,ARPC5L,PIK3R5,PIK3CG |
| Viral carcinogenesis | RAC1,UBE3A,HIST1H4A,ACTN4,HIST2H4,TBP,PRKACB,VAC14,HIST1H4M,HRAS |
| Regulation of Actin Cytoskeleton | MAP2K2,TMSB4X,PIP5K1BB,SLC9A1,ROCK2A,ACTN2B,GSN,MAP2K2A,PIP4K2B,SSH1 |
Protein Function
SCIN has several biochemical functions, for example, 1-phosphatidylinositol binding,actin binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCIN itself. We selected most functions SCIN had, and list some proteins which have the same functions with SCIN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | TLL1,MEX3B,JAG2,UBE4A,HPGDS,PPP3R1,CRELD1,DAG1,PCDHB15,CAPN2 |
| actin filament binding | SYNE3,MYO10,PKNOX2,MAP1S,ACTN2,DBNL,JUB,AJUBA,SLC6A4,TTN |
| phosphatidylinositol-4,5-bisphosphate binding | KRIT1,LDLRAP1,PFN2,ADAP2,MAPKAP1,SYT1,D6WSU116E,MYO1G,FAM21C,RAB35 |
| 1-phosphatidylinositol binding | PLEKHA3,SNX10,SNAP91,CCDC167,SYT1,SNX9,SCARB1,PICALM,PLEKHA2,ZFYVE9 |
| actin binding | EZRB,VASPA,VASP,LRRC10,AFAP1,DIAP3,ADD2,PFN3,PLS3,GMFB |
| phosphatidylserine binding | SCARB1,SYT4,FCHO2,OSBPL5,MFGE8,CD300A,OSBPL8,AP1S2,CPNE1,THBS1 |
Interacting Protein
SCIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SCIN.
MAP3K3;RIPK3;GRB2
Resources
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References
- Swierstra, J; Debets, S; et al. IgG4 Subclass-Specific Responses to Staphylococcus aureus Antigens Shed New Light on Host-Pathogen Interaction. INFECTION AND IMMUNITY 83:492-501(2015).
- Garcia, BL; Ramyar, KX; et al. Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins. CURRENT TOPICS IN INNATE IMMUNITY II 946:113-133(2012).
