SATB1
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Official Full Name
SATB homeobox 1 -
Overview
Special AT-rich binding protein 1 (SATB1) functions as both a global chromatin organizer and a gene-specific transcription factor. SATB1 cooperates with promyelocytic leukemia protein (PML) to regulate global chromatin architecture by organizing chromatin -
Synonyms
SATB1;SATB homeobox 1;special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA);DNA-binding protein SATB1;special AT-rich sequence-binding protein 1;special AT-rich sequence binding protein 1 (binds to nuclear matr
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
SATB1 involved in several pathways and played different roles in them. We selected most pathways SATB1 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with SATB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptotic cleavage of cellular proteins | ADD1,VIML,LMNB1,DSG2,PLEC,DBNLB,OCLN,DSG1,CASP6L1,PKP1 |
| Caspase cascade in apoptosis | CASP2,GAS2,ACTA1,LMNB1,NUMA1,CFL2,DIABLO,CASP4,CRADD,TFAP2A |
| Apoptotic execution phase | DBNLB,DSG1,STK26,HIST1H1E,DNM1L,STK24A,SPNA2,LMNB1,CASP8L1,STK24B |
| Programmed Cell Death | CASP6L2,DNM1L,DSG3,STK24,DSG2,VIML,GAS2,STK26,DSG1,DBNLA |
| Apoptosis | PIK3CD,DCC,RIPK1,GZMF,JUN,DBNL,DSG3,DBNLA,IL1A,DIABLOB |
Protein Function
SATB1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SATB1 itself. We selected most functions SATB1 had, and list some proteins which have the same functions with SATB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | MTERF,SAFB,MCM10,MEN1,IFI203,TP63,SETMAR,GTF2H4,PIN4,ZNF638 |
| protein binding | SMOC1,KIAA1267,COMTD1,MAD2L2,SEC22A,CALCRL,TRIM67,BCAM,UBA52,BCL11A |
| chromatin binding | CREB3,SUPT5H,AJUBA,UBTFL,ASH1L,GATA2B,SMARCA2,POLR2B,HMGB4,EWSR1A |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF5,PRDM15,DMBX1,PLAGL1,SNAI1,TFAP2E,POGZA,DMRT1,RXRG,GATA5 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | NR2F6,ARID5B,KLF6A,ETV3,HMX1,JARID2,DMBX1,POU5F1,ZNF350,CDX2 |
Interacting Protein
SATB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SATB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SATB1.
g2xkq0_human;UBE2I;SUMO1;CASP6;CBX4;PIAS1;tolC;PIAS4;TOPORS;PIAS3;ssdna_dadts;PYHIN1
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References
- Hedner, C; Gaber, A; et al. SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma. VIRCHOWS ARCHIV 465:649-659(2014).
- Kobierzycki, C; Wojnar, A; et al. Expression of SATB1 protein in the ductal breast carcinoma tissue microarrays - preliminary study. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA 51:333-338(2013).
