SAP30

  • Official Full Name

    Sin3A-associated protein, 30kDa

  • Overview

    Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.

  • Synonyms

    SAP30;Sin3A-associated protein, 30kDa;sin3A associated protein, 30kDa;histone deacetylase complex subunit SAP30;sin3-associated polypeptide p30;30 kDa Sin3-associated polypeptide;Sin3-associated polypeptide, 30kDa;sin3-associated polypeptide, 30 kDa;Sin3 corepressor complex subunit SAP30

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SAP30-3031H Recombinant Human SAP30 protein, His-tagged E.coli Human His 68 - 197 aa
SAP30-14669M Recombinant Mouse SAP30 Protein Mammalian Cells Mouse His
SAP30-4072R Recombinant Rhesus monkey SAP30 Protein, His-tagged Mammalian Cells Rhesus macaque His
SAP30-1559HCL Recombinant Human SAP30 cell lysate Human Non
SAP30-3889R Recombinant Rhesus Macaque SAP30 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SAP30-3889R-B Recombinant Rhesus Macaque SAP30 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SAP30-7899M Recombinant Mouse SAP30 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SAP30-7899M-B Recombinant Mouse SAP30 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SAP30 involved in several pathways and played different roles in them. We selected most pathways SAP30 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HDACs deacetylate histones MBD3A,MTA1,SUDS3,SAP30L,GATAD2AB,HMG20B,PHF21A,CHD4A,KDM1A,GATAD2A
    Hedgehog signaling events mediated by Gli proteins MTSS1,IFT88,SIN3B,CSNK1G2,CSNK1G3,LGALS3,KIF3A,SPOP,SAP18
    Delta-Notch Signaling Pathway ADAM10A,ASCL1A,NOV,SMAD3B,RING1,CNTN1,APPA,CNTFR,ASCL1,MAGEA1
    Chromatin organization COPRS,MORF4L2,TADA1,SMARCB1,MSL1A,ATF7IP,KDM4B,TADA2A,ATXN7L3,AEBP2
    Chromatin modifying enzymes HMG20B,PRMT5,ELP4,SMARCE1,DNMT3A,ATF7IP,ARID2,BRPF1,MSL2,SUDS3
    Negative epigenetic regulation of rRNA expression SAP30L,EFCAB11,SUDS3,TAF1A,TAF1C,RRP8,DNMT3B,SAP30BP,TAF1D,SIN3B
    Epigenetic regulation of gene expression SUDS3,TAF1A,TAF1D,SUZ12B,TAF1C,EED,RBB4L,AEBP2,PHF1,BAZ2A
    Gene Expression NR2C1,ZNF584,ZNF718,CHD4,TXN,COX6A1,ZNF302,FAM36A,NR2F1A,C7orf59

    Protein Function

    SAP30 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP30 itself. We selected most functions SAP30 had, and list some proteins which have the same functions with SAP30. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding AGMAT,ZNF559-ZNF177,ZDHHC21,COL5A1,KLK1B4,DROSHA,BRIP1,MAP3K3,PAK3,PLCD3A
    transcription corepressor activity HOMEZA,CITED2,NCOR1,TLE4,JAZF1,MAP3K10,ZFPM2,ANKRD1,DR1,MYBBP1A
    DNA binding BHLHA15,HIVEP2,TIGD6,ZBTB41,GSX1,MLF1,HBP1,POLR3A,LBX2,ZMAT4
    protein binding COIL,LDLRAP1,TJAP1,FIGNL1,RAD17,ARHGEF12,CENPA,SZL,PLA2G16,RABGAP1L

    Interacting Protein

    SAP30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP30 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP30.

    HDAC1;HDAC2;SIN3A;NCOR2;CIR1;Max;BRMS1;SAP130;TNRC18;SIN3B;SIN3B;ARID4A;FOXK1;FOXK2;SMC1A

    SAP30 Related Signal Pathway

    Resources

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