Ryr2

  • Official Full Name

    ryanodine receptor 2, cardiac

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&Fc&Avi

    Involved Pathway

    Ryr2 involved in several pathways and played different roles in them. We selected most pathways Ryr2 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ryr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway PLCD1B,TACR1,HTR5A,CAMK2D,ATP2B4,PLCB1,SLC25A5,DRD7,PLCB2,GRIN2D
    cAMP signaling pathway CALM4,OXTR,GPR119,BAD,PPP1CC,GRIN3A,FXYD2,PDE4B,CNGA2,MAP2K1
    Dilated cardiomyopathy ACTG1,ITGA6,DMD,ITGB7,PLN,SGCD,SGCG,MYL2,PRKACB,CACNB4
    Hypertrophic cardiomyopathy (HCM) TPM3,SGCA,ITGA5,LMNA,CACNG6,MYL3,ITGB6,ITGB1,CACNB3,ACTC1
    Insulin secretion Adcy4,RAPGEF4,GIP,GNAQ,PRKACA,CAMK2A,INS,KCNMB2,SLC2A1,FFAR1
    Adrenergic signaling in cardiomyocytes CALM2,MYL3,AGTR1,CAMK2G,MAPK12B,CACNG6,ADRB3A,ATP1A1,CACNA1SA,ATP1A3
    Cardiac muscle contraction CACNG6A,COX7B2,VMHCL,ATP1A3B,ATP1A3,COX5A,ATP1B3A,CACNG3,FXYD2,MYH7
    Pancreatic secretion PLA2G5,ATP2B1,CPA1,PLA2G1B,CTRB1,TPCN2,CLCA2,Adcy4,ATP1B4,PLCB2
    Oxytocin signaling pathway PRKACG,CACNG7,ACTG1,MAPK7,PPP1R12A,CAMKK1,ROCK1,PLA2G4C,PIK3CB,CAMKK2

    Protein Function

    Ryr2 has several biochemical functions, for example, calcium channel activity,calcium ion binding,calcium-induced calcium release activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ryr2 itself. We selected most functions Ryr2 had, and list some proteins which have the same functions with Ryr2. You can find most of the proteins on our site.

    Function Related Protein
    calcium-release channel activity RYR3,TRPV1,RASA3,JPH2,JPH3,RYR1
    enzyme binding PRKCE,POR,HMGA1,WWOX,SLC27A2,Il6ra,FOXO4,LDB1,TOP2A,PDE4DIP
    protein kinase A regulatory subunit binding ARFGEF1,AKAP7,AKAP8,AKAP9,ACBD3,KCNQ1,AKAP1,AKAP5,ARFGEF2,AKAP6
    calcium ion binding ARSA,FBN2B,MMP11,SLC24A1,PCDHGA11,PCDHGC4,ITIH1,AGRN,NOTCH1A,LDLRB
    ryanodine-sensitive calcium-release channel activity RYR1,RYR1B,RYR3
    calmodulin binding MYH1,DAPK2,CAMK1D,SPTAN1,IQCB1,ATPIF1,MYH4,NOS1,PLCB3,ASPM
    ion channel binding CTNNB1,PPP1R9B,YWHAQ,PIRT,RIMS1,ACTN4,ACTN1,YWHAE,FYN,FAM115A
    intracellular ligand-gated calcium channel activity ITPR3,AKR1C1,ITPR1,TRPA1
    protein kinase A catalytic subunit binding KCNQ1,SOX9,GSK3B,PRKAR2A,GSK3A,EZR,PRKAR1A,PRKAR2B,PJA2,PRKAR1B

    Interacting Protein

    Ryr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ryr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ryr2.

    FKBP1B;MDM2;PRKACA;FKBP1A;vgrG7;q81z75_bacan;SMAD5;ALB;CFTR;AKAP6

    Resources

    References

    • Moore, CJ; Shao, CH; et al. Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes. MOLECULAR AND CELLULAR BIOCHEMISTRY 376:121-135(2013).
    • Qiu, AW; Yang, Q; et al. Interleukin-6 prevents NMDA-induced neuronal death via Gp130 signaling-dependent IP3R inhibition. NEUROENDOCRINOLOGY LETTERS 34:529-538(2013).

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