RYR1
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Official Full Name
ryanodine receptor 1 (skeletal) -
Overview
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene. -
Synonyms
RYR1;ryanodine receptor 1 (skeletal);ryanodine receptor 1;skeletal muscle calcium release channel;skeletal muscle ryanodine receptor;skeletal muscle-type ryanodine receptor;type 1 ryanodine receptor;RYR-1
Recombinant Proteins
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- His
- His&GST
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RYR1-357H | Recombinant Human RYR1 | Mammalian Cell | Human | His |
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| RYR1-2037H | Recombinant Human RYR1 Protein, His&GST-tagged | E.coli | Human | His&GST | His97-Cys392 |
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| Ryr1-2038R | Recombinant Rat Ryr1 Protein, His-tagged | E.coli | Rat | His | His99-Cys394 |
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| Ryr1-2669M | Recombinant Mouse Ryr1 Protein, His&GST-tagged | E.coli | Mouse | His&GST | His99-Cys394 |
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| RYR1-301225H | Recombinant Human RYR1 protein, GST-tagged | E.coli | Human | GST | Gly4942-Ser5038 |
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| RYR1-4018H | Recombinant Human RYR1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RYR1-4018H-B | Recombinant Human RYR1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| RYR1-789H | Recombinant Human RYR1 Protein (1-534 aa), His-tagged | E.coli | Human | His | 1-534 aa |
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| RYR1-790H | Recombinant Human RYR1 protein (Skeletal), His-tagged | E.coli | Human | His | His97-Cys392 |
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Involved Pathway
RYR1 involved in several pathways and played different roles in them. We selected most pathways RYR1 participated on our site, such as Calcium signaling pathway,Circadian entrainment,Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxytocin signaling pathway | CACNG8,ROCK2,ELK1,PRKAB2,NRAS,PRKAB1,PIK3R2,CAMK1G,NOS3,KCNJ14 |
| Long-term depression | PPP2CA,PLA2G4F,PLA2G4C,ARAF,GNAI2,LYN,ITPR1,GNAS,MAP2K2,GNAO1 |
| Circadian entrainment | Adcy4,ITPR1,FOS,GNG13,GNB3,PRKG1,GNG3,PLCB3,PER2,CACNA1G |
| Calcium signaling pathway | CYSLTR1,ERBB4A,GNA15.1,ADRA1D,PRKCBB,CALM2B,P2RX1,ERBB2,PHKA1,ATP2A2 |
Protein Function
RYR1 has several biochemical functions, for example, calcium channel activity,calcium-release channel activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RYR1 itself. We selected most functions RYR1 had, and list some proteins which have the same functions with RYR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GRB2,FUZ,WBP4,KRR1,FIS1,RNF135,SFPI1,SLC9A3R1,RABAC1,CD59 |
| calcium-release channel activity | RYR3,TRPV1,JPH3,RASA3,RYR2,JPH2 |
| protease binding | TNF,FLOT2,NDUFS7,PANX1,ADAM8A,ECM1,TRIP4,DVL3,ELANE,SERPINE1 |
| ryanodine-sensitive calcium-release channel activity | RYR1B,RYR2,RYR3 |
| calcium channel activity | GRIN2B,SLC24A2,CACNG8A,PDE2A,TRPC3,P2RX1,PKD2L1,TPCN1,RYR2,CACNA1BA |
| voltage-gated calcium channel activity | CACNB2A,CACNG8A,NCS1,CACNG3,CACNG7,CACNG8,CACNA2D1,CACNA1SA,CACNG2,CACNG2A |
| calmodulin binding | ADCY3,MTAP6,CNN3,KCNH5,MYO1C,NOS2,SPTAN1,SRY,CAMK2D1,SNTB1 |
Interacting Protein
RYR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RYR1.
MYOM2;PPP1CA;PPP2CA;NCK1;PLCG1;GRB2;TULP3;PDLIM3;TTN;TF
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References
- Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).
- Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).
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Cat#RYR1-4018H does include a.a.799-1175, we can custom produce this domain for you. Please find below the pricing information for this item.