RXFP2
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Official Full Name
relaxin/insulin-like family peptide receptor 2 -
Overview
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RXFP2;relaxin/insulin-like family peptide receptor 2;leucine rich repeat containing G protein coupled receptor 8 , LGR8;relaxin receptor 2;GPR106;GREAT;INSL3R;RXFPR2;G protein coupled receptor 106;G protein coupled receptor affecting testicular descent;Leucine rich repeat containing G protein coupled receptor 8;LGR8;Relaxin family peptide receptor 2;RXFP 2;OTTHUMP00000018219;G-protein coupled receptor 106;G-protein coupled receptor affecting testicular descent;leucine-rich repeat-containing G protein-coupled receptor 8;leucine-rich repeat-containing G-protein coupled receptor 8;LGR8.1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mus musculus
- Dog
- Mammalian Cell
- HEK293
- E.coli expression system
- E.coli
- His
- Non
- His&Fc&Avi
- His&Myc
Involved Pathway
RXFP2 involved in several pathways and played different roles in them. We selected most pathways RXFP2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (s) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RXFP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide ligand-binding receptors | RLN3,NMB,SSTR5,NPB,TAC3,GPR37B,CCL27,EDN3,PENKB,PROK2 |
| Class A/1 (Rhodopsin-like receptors) | S1PR5B,QRFP,CCK,SSTR5,DRD5,OPN4A,FPR-RS4,OPN1SW,QRFPR,PRLH |
| G alpha (s) signalling events | RAMP1,INSL3,GPBAR1,PTH2,CRHB,CGA,RLN3,RLN2,SCT,VIP |
| Neuroactive ligand-receptor interaction | OPRL1,SSTR1,THRB,CHRM2A,GNRHR4,CSH,PTGER1A,KISS1RA,NPFFR1L2,HTR7 |
| Myometrial Relaxation and Contraction Pathways | RGS6,RGS4,CORIN,MYLK2,GUCA2A,CNN1,ADM,GPR182,RGS14,RGS11 |
| GPCR downstream signaling | LPAR1,ADCYAP1B,RGS7,LPAR5A,RAMP2,SCT,ARHGAP4,S1PR5B,HRH3,PENK |
| Relaxin receptors | RLN2,INSL5,RLN3A,RLN3,INSL3 |
| GPCR ligand binding | NTS,QRFP,KISS1,NMBA,PTHLHA,PTH,ADCYAP1R1,HCAR1-2,CCL27,EDNRA |
Protein Function
RXFP2 has several biochemical functions, for example, peptide hormone binding,protein-hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RXFP2 itself. We selected most functions RXFP2 had, and list some proteins which have the same functions with RXFP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone binding | NPR1,GALR3,AVPR1A,GHRHR,MC4R,OXTR,GCGR,GALR2,NPR2,MC3R |
| protein-hormone receptor activity | GNRHR2,LGR4,GNRHR3,GNRHR1,GNRHR4 |
Interacting Protein
RXFP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RXFP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RXFP2.
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References
- Fenichel, P; Lahlou, N; et al. Cord blood Insulin-like peptide 3 (INSL3) but not testosterone is reduced in idiopathic cryptorchidism. CLINICAL ENDOCRINOLOGY 82:242-247(2015).
- Nair, VB; Bathgate, RAD; et al. Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability. Biomed Research International :-(2015).
