RSPO4
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Official Full Name
R-spondin family, member 4 -
Synonyms
A730099F22;A930029K19Rik
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RSPO4-3715H | Recombinant Human RSPO4 protein, His-tagged | E.coli | Human | His | 163-234 aa | |
| RSPO4-1001H | Recombinant Human RSPO4 | Mammalian Cell | Human | His |
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| RSPO4-8401Z | Recombinant Zebrafish RSPO4 | Mammalian Cell | Zebrafish | His |
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| RSPO4-301500H | Recombinant Human RSPO4 protein, GST-tagged | E.coli | Human | GST | Leu163-Pro234 |
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| RSPO4-4014H | Recombinant Human RSPO4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RSPO4-4014H-B | Recombinant Human RSPO4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
RSPO4 involved in several pathways and played different roles in them. We selected most pathways RSPO4 participated on our site, such as Regulation of FZD by ubiquitination,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Wnt | BCL9,TNKS2,TMED5,ZNRF3,SOX9A,KLHL12,SOX4B,CBY1,C,PYGO1 |
| TCF dependent signaling in response to WNT | KLHL12,SOX32,RNF146,SOX9B,DACT1,ZNRF3,PYGO2,RSPO3,SOX4B,TLE3B |
| Regulation of FZD by ubiquitination | RNF43,LGR5,RSPO1,RSPO3,ZNRF3,LGR6,LGR4,RSPO2,FMNL3 |
| Signal Transduction | APOM,FAM105B,ARHGAP36,LPAR5A,METAP2,HEBP1,RHOUA,PCSK6,GDI1,USP9 |
Protein Function
RSPO4 has several biochemical functions, for example, G-protein coupled receptor binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO4 itself. We selected most functions RSPO4 had, and list some proteins which have the same functions with RSPO4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | NELL2,FGF2,LTF,WISP1A,PTPRF,LPL,FGFR1,AZU1,APOE,APOH |
| G-protein coupled receptor binding | CORT,FCN1,GNA13B,POMC,ADORA1,GNAT2,GNA13A,UCN3,AKAP5,GNA15.4 |
Interacting Protein
RSPO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO4.
RSPO4 Related Signal Pathway
Resources
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References
- Xu, JG; Huang, CF; et al. Crystal Structure of LGR4-Rspo1 Complex INSIGHTS INTO THE DIVERGENT MECHANISMS OF LIGAND RECOGNITION BY LEUCINE-RICH REPEAT G-PROTEIN-COUPLED RECEPTORS (LGRs). JOURNAL OF BIOLOGICAL CHEMISTRY 290:2455-2465(2015).
- Carmon, KS; Gong, X; et al. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E1221-E1229(2014).
