RRP8
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Official Full Name
ribosomal RNA processing 8, methyltransferase, homolog (yeast) -
Overview
Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene. -
Synonyms
RRP8;ribosomal RNA processing 8, methyltransferase, homolog (yeast);KIAA0409;ribosomal RNA-processing protein 8;RRP8 methyltransferase homolog (S. cerevisiae);Cerebral protein 1;hypothetical protein LOC23378;Nucleomethylin;Ribosomal RNA processing 8 methyltransferase homolog;Ribosomal RNA processing protein 8;RRP 8;RRP8 methyltransferase homolog
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RRP8-14534M | Recombinant Mouse RRP8 Protein | Mammalian Cell | Mouse | His |
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| RRP8-5184R | Recombinant Rat RRP8 Protein | Mammalian Cell | Rat | His |
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| RRP8-2140HCL | Recombinant Human RRP8 293 Cell Lysate | HEK293 | Human | Non |
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| RRP8-2469H | Recombinant Human RRP8 protein(81-270 aa), C-His-tagged | E.coli | Human | His | 81-270 aa |
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| RRP8-4843R | Recombinant Rat RRP8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RRP8-4843R-B | Recombinant Rat RRP8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RRP8-7821M | Recombinant Mouse RRP8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RRP8-7821M-B | Recombinant Mouse RRP8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RRP8 involved in several pathways and played different roles in them. We selected most pathways RRP8 participated on our site, such as Epigenetic regulation of gene expression,Gene Expression,Negative epigenetic regulation of rRNA expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | TSEN34,POU2F1,EEF1A1,NR2E1,MBD3B,CBX3A,ZNF114,SEC61B,CSTF3,PDCD7 |
| Epigenetic regulation of gene expression | SAP30L,PHF19,SUZ12,MTF2,SAP130,DNMT1,BAZ2A,SUDS3,EED,TAF1A |
| Negative epigenetic regulation of rRNA expression | TAF1D,DNMT1,EFCAB11,CD3EAP,SAP18,SIN3B,SAP130,SAP30L,SAP30,DNMT3B |
Protein Function
RRP8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity,methylated histone binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRP8 itself. We selected most functions RRP8 had, and list some proteins which have the same functions with RRP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRHR1,LEO1,MAP3K8,TFIP11,ZNF404,PSMB2,PPP2R5B,ORAI2,EHHADH,EEF1A1 |
| S-adenosylmethionine-dependent methyltransferase activity | METTL7A,AS3MT,MEPCE,LCMT2,COQ5,LSM1,PRMT8B,ASMT2,LCMT1,C6orf211 |
| methylated histone binding | FAM156A,CAPNS2,CBX7,CHD1,ZMYND11,WDR92,ING4,MTF2,TP53BP1,ING1 |
| poly(A) RNA binding | MANF,DDX52,EIF4H,NUPL2,DAZAP1,G3BP2,NOP2,CSRP1,THUMPD1,UTP18 |
Interacting Protein
RRP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRP8.
SUV39H1;SIRT1;h3_peptide-2-21;s-adenosyl-l-methionine-1;USP39;BALF3 (provisional);MNDA;ILK
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References
- Peifer, C; Sharma, S; et al. Yeast Rrp8p, a novel methyltransferase responsible for m(1)A 645 base modification of 25S rRNA. NUCLEIC ACIDS RESEARCH 41:1151-1163(2013).
- Sharma, S; Watzinger, P; et al. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. NUCLEIC ACIDS RESEARCH 41:5428-5443(2013).
- Schilling, V; Peifer, C; et al. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. YEAST 29:167-183(2012).
- Bousquet-Antonelli, C; Vanrobays, E; et al. Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2. RNA-A PUBLICATION OF THE RNA SOCIETY 6:826-843(2000).
