RPL10A
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Official Full Name
ribosomal protein L10a -
Overview
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. -
Synonyms
RPL10A;ribosomal protein L10a;NEDD6;60S ribosomal protein L10a;Csa 19;L10A;NEDD-6;neural precursor cell expressed developmentally down-regulated protein 6;Csa-19
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
RPL10A involved in several pathways and played different roles in them. We selected most pathways RPL10A participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL24,RPS8,MRPS10,RPS17,RPL34-PS1,RPL3,MRPL16,RPS9,MRPL28,RPL22L1 |
Protein Function
RPL10A has several biochemical functions, for example, poly(A) RNA binding,protein binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL10A itself. We selected most functions RPL10A had, and list some proteins which have the same functions with RPL10A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | RPS21,MRPS16,RPS17L,RPL11,RPL5,MRPS24,MRPL47,RPS3,MRPS33,RPS27.1 |
| protein binding | MAGEF1,SZL,MRPS27,NUP62CL,VAT1L,ORAI2,CYTIP,FCGR2A,THBS1,ARL3 |
| poly(A) RNA binding | ACTN4,DDX5,NOVA2,FYTTD1,SRSF1,SSRP1,CCBL2,KPNB1,RPS24,EBNA1BP2 |
Interacting Protein
RPL10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL10A here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL10A.
RGS17;VCAM1;LRRK2;YWHAZ;MAP3K1;MAP3K14;SRPR;ACTB;midostaurin;Srp72;NOP56;Smad6;GABARAP
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References
- Grgic, I; Hofmeister, AF; et al. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. KIDNEY INTERNATIONAL 86:1116-1129(2014).
- Drane, L; Ainsley, JA; et al. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. FRONTIERS IN MOLECULAR NEUROSCIENCE 7:-(2014).
