RPGRIP1L
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Official Full Name
RPGRIP1-like -
Overview
The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RPGRIP1L;RPGRIP1-like;protein fantom;CORS3;fantom homolog;FTM;JBTS7;KIAA1005;Meckel syndrome;type 5;MKS5;NPHP8;nephrocystin 8;nephrocystin-8;RPGRIP1-like protein;RPGR-interacting protein 1-like protein;DKFZp686C0668
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RPGRIP1L-14399M | Recombinant Mouse RPGRIP1L Protein | Mammalian Cell | Mouse | His |
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| RPGRIP1L-3967R | Recombinant Rhesus monkey RPGRIP1L Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RPGRIP1L-8097Z | Recombinant Zebrafish RPGRIP1L | Mammalian Cell | Zebrafish | His |
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| RPGRIP1L-3784R | Recombinant Rhesus Macaque RPGRIP1L Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RPGRIP1L-3784R-B | Recombinant Rhesus Macaque RPGRIP1L Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RPGRIP1L-7716M | Recombinant Mouse RPGRIP1L Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RPGRIP1L-7716M-B | Recombinant Mouse RPGRIP1L Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RPGRIP1L involved in several pathways and played different roles in them. We selected most pathways RPGRIP1L participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPGRIP1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog on state | KIF7,KIF3A,MKS1,BOC,IFT172,EVC,GPR161,CDON,IQCE,SPOP |
| Hedgehog off state | IFT122,TTC21B,KIF7,MKS1,WDR35,WDR19,TULP3,IFT52,INTU,GPR161 |
| Assembly of the primary cilium | IFT46,UNC119.1,CEP97,KIF3A,TUBB4A,NEDD1,TTC30B,FGFR1OP,CSNK1D,DYNLL2 |
| Organelle biogenesis and maintenance | UNC119.1,MRPL52,RP2,BBS2,CC2D2A,IFT52,CEP89,BBS12,MRPS31,B9D1 |
| Anchoring of the basal body to the plasma membrane | NEK2,CC2D2A,RAB3IP,BBS13,CLASP1A,TCTN3,CP110,CLASP1,MKS1,CEP57 |
| Signal Transduction | FAM13B1,ARHGAP36,RLBP1,MDK,DTX2,PRICKLE1,OPN4B,DEPDC7,FSTL3,GRAP |
| Signaling by Hedgehog | EVC2,IQCE,TULP3,EFCAB7,DISP2,GAS8,KIF7,INTU,SPOPL,IFT88 |
Protein Function
RPGRIP1L has several biochemical functions, for example, protein binding,thromboxane A2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPGRIP1L itself. We selected most functions RPGRIP1L had, and list some proteins which have the same functions with RPGRIP1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DHRS1,PARVA,MUM1,IFNAR2,HHLA2,GABARAPL1,SENP1,GHR,CHRM3,SH2B2 |
Interacting Protein
RPGRIP1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPGRIP1L here. Most of them are supplied by our site. Hope this information will be useful for your research of RPGRIP1L.
Nphp4;Iqcb1;Ddx5;Ambra1;Ubr4;Lrp2;Ccdc171;Aldoart1;Cad;Gcn1l1;Dsp;a2cf96_mouse;Dpysl2;Stxbp1;Utrn
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