RNF8
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Official Full Name
ring finger protein 8, E3 ubiquitin protein ligase -
Overview
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] -
Synonyms
RNF8;ring finger protein 8, E3 ubiquitin protein ligase;hRNF8;E3 ubiquitin-protein ligase RNF8;C3HC4-type zinc finger protein;ring finger protein (C3HC4 type) 8;UBC13/UEV-interacting ring finger protein
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- Human
- Mammalian Cell
- HEK293
- E.coli
- Insect Cell
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
RNF8 involved in several pathways and played different roles in them. We selected most pathways RNF8 participated on our site, such as Apoptosis,Axon guidance,Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | TCF4,MYOD1,EPHB4A,PAQR3B,EPHA2,DAB2IPB,NR6A1,CTNNA2,GDF1,ST8SIA2 |
| Programmed Cell Death | GZME,MLKL,DAPK1,DBNL,STK24A,DSP,DNM1L,DBNLB,CASP6L2,DBNLA |
| Netrin mediated repulsion signals | UNC5D |
| Caspase activation via extrinsic apoptotic signalig pathway | DAPK1,CASP8L1,TICAM1,DCC,DAPK3 |
| Apoptosis | IKBKB,PLECA,PIK3R5,PKP1,BIRC5A,TRADD,IRF6,HIST1H1D,TICAM1,DNM1L |
| Netrin-1 signaling | RGMA,RGMB,PITPNA,NTN1A,SIAH2,EZRA,TRPC4,TRPC5,NTN1B,UNC5D |
| Axon guidance | CSNK2B,PLXND1,ABLIM3,COL4A4,NTN1,SDCBP,PLXNA3,RHOA,SLIT1,PAK6 |
| Ligand-independent caspase activation via DCC | DAPK1,DAPK3 |
Protein Function
RNF8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RNF8 itself. We selected most functions RNF8 had, and list some proteins which have the same functions with RNF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
RNF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF8.
MDC1;WASL;PNMA2;rnf8_bind_peptide
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