RNF19A
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Official Full Name
ring finger protein 19A -
Overview
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinsons disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported. -
Synonyms
RNF19A;ring finger protein 19A;ring finger protein 19 , RNF19;E3 ubiquitin-protein ligase RNF19A;DKFZp566B1346;dorfin;AA032313;Double ring finger protein;Double ring-finger protein;p38;p38 protein;Ring finger protein 19;Ring IBR ring domain containing protein Dorfin;RN19A_HUMAN;RNF19;Ubce7ip2;UIP117;XYbp;OTTHUMP00000227271;OTTHUMP00000227364;RING finger protein 19 isoform;ring-IBR-ring domain containing protein Dorfin;protein p38 interacting with transcription factor Sp1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF19A-14328M | Recombinant Mouse RNF19A Protein | Mammalian Cell | Mouse | His |
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| RNF19A-2285HCL | Recombinant Human RNF19A 293 Cell Lysate | HEK293 | Human | Non |
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| RNF19A-7671M | Recombinant Mouse RNF19A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RNF19A-7671M-B | Recombinant Mouse RNF19A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RNF19A involved in several pathways and played different roles in them. We selected most pathways RNF19A participated on our site, such as Parkin-Ubiquitin Proteasomal System pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF19A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkin-Ubiquitin Proteasomal System pathway | TUBA3D,STUB1,TUBB7P,HSPA14,SIAH2,UBE2J2,TUBA1B,TUBA3E,HSPA7 |
Protein Function
RNF19A has several biochemical functions, for example, ligase activity,transcription factor binding,ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF19A itself. We selected most functions RNF19A had, and list some proteins which have the same functions with RNF19A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | CBLC,SMURF1,RNF175,RNF122,RNF111,BTRC,FBXW11,UBE2NB,UBE2W,MDM2 |
| transcription factor binding | TWIST1,RBFOX2,NKX2,PIM1,HES4,TFDP1,TFDP1B,LMO4,BCL3,DIP2B |
| ligase activity | RNF138,NAPRT,TNFAIP3,TRIM71,KCMF1,RNF144B,HERC2,ZNRF1,MEX3C,GATB |
| zinc ion binding | PHF19,BTR18,TRIM61,RNF10,PEX10,MSL2,POLR2I,ING4,ZCCHC11,GFI1AB |
| ubiquitin conjugating enzyme binding | RNF144AB,MARCH6,UBE2V1,DCUN1D2A,DCUN1D5,DCUN1D4,ARIH1L,PPARA,ARIH1,DCUN1D3 |
Interacting Protein
RNF19A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF19A here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF19A.
SP1;SMAP;MAP3K7;NUDT21;RPS6KA5;ILK;ZAK
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