RNF146
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Official Full Name
ring finger protein 146 -
Overview
RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene. -
Synonyms
RNF146;ring finger protein 146;E3 ubiquitin-protein ligase RNF146;dactylidin;dJ351K20.1;DKFZp434O1427;RP3 351K20.1;RN146_HUMAN;RNF 146;2610509H23Rik;RP3-351K20.1
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Cynomolgus
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi
- Fc
Involved Pathway
RNF146 involved in several pathways and played different roles in them. We selected most pathways RNF146 participated on our site, such as Degradation of AXIN,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF146 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Wnt | BCL9L,RNF43,ZNRF3,ROR1,USP34,C,PYGO2,RSPO2,SOX32,LGR5 |
| TCF dependent signaling in response to WNT | SOX9A,HECW1,LEO1,TNKS2,WIF1,ASH2L,RSPO1,SOX6,WNT8-2,CBY1 |
| Signal Transduction | KDM4C,STRA6,CALCB,RLN3,CUL5A,ARHGEF1A,SOX32,RTN4A,IQCE,GHRH |
| Degradation of AXIN | TNKS2,TNKS |
Protein Function
RNF146 has several biochemical functions, for example, ligase activity,poly-ADP-D-ribose binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF146 itself. We selected most functions RNF146 had, and list some proteins which have the same functions with RNF146. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM56,TRAF7,NSMCE1,RNF4,TRIM6,UFL1,G2E3,RNF216,UHRF1,PPIL2 |
| ubiquitin protein ligase activity | UBE2J1,RNF222,ARIH1,PRPF19,CDC34B,TRAIP,CDC34A,RAD18,C12orf51,UBE2B |
| ubiquitin-protein transferase activity | ARIH1,TRIM69,RNF125,FBXO2,BARD1,FBXO3,PAX6,UBE2C,ARIH1L,TRAF4B |
| protein binding | SLC9A3R1,TMEM11,CTAGE5,RAD9A,BBS9,RP9,UBD,COPS7B,CSN3,HIST1H4E |
| zinc ion binding | CNBP,MECR,ZCCHC10,EP300,ERI2,MYT1,RARAA,RPH3A,ZFAND6,CHMP1A |
Interacting Protein
RNF146 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF146 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF146.
TRAF2;CCDC155;TUBGCP4;Sh3bp2;PFN2;UBE2G2;UBE2H
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References
- Gero, D; Szoleczky, P; et al. Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes. MOLECULAR MEDICINE 20:313-328(2014).
- Gao, Y; Song, CY; et al. Overexpression of RNF146 in Non-Small Cell Lung Cancer Enhances Proliferation and Invasion of Tumors through the Wnt/beta-catenin Signaling Pathway. PLOS ONE 9:-(2014).
