RNF103
-
Official Full Name
ring finger protein 103 -
Overview
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. -
Synonyms
RNF103;ring finger protein 103;ZFP103, zinc finger protein 103 homolog (mouse);E3 ubiquitin-protein ligase RNF103;hkf 1;KF1;RNF 103;ZFP 103;Zinc Finger Protein 103;Zinc finger protein expressed in cerebellum;Zinc finger protein homologous to Zfp103 in mouse;OTTHUMP00000203333;zinc finger protein 103 homolog;KF-1;HKF-1;ZFP103;ZFP-103
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RNF103 involved in several pathways and played different roles in them. We selected most pathways RNF103 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF103 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RNF103 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RNF103 itself. We selected most functions RNF103 had, and list some proteins which have the same functions with RNF103. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
RNF103 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF103 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF103.
Resources
Related Services
Related Products
References
- Xing, CY; Zhou, WH; et al. Reversing Effect of Ring Finger Protein 43 Inhibition on Malignant Phenotypes of human Hepatocellular Carcinoma. MOLECULAR CANCER THERAPEUTICS 12:94-103(2013).
- Kashimoto, K; Komatsu, S; et al. Overexpression of TRIM44 contributes to malignant outcome in gastric carcinoma. CANCER SCIENCE 103:2021-2026(2012).
