RLN3
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Official Full Name
relaxin 3 -
Overview
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. -
Synonyms
RLN3;relaxin 3;relaxin 3 (H3);relaxin-3;H3;RXN3;ZINS4;prorelaxin H3;insulin-like 7;insulin-like peptide 7;insulin-like peptide INSL7;insl7
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
RLN3 involved in several pathways and played different roles in them. We selected most pathways RLN3 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RLN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | GPR132B,PTHLH,TAS2R13,VIP,NMU,LTB4R,KISS1,GPR4,RHOGA,DRD5 |
| Relaxin receptors | INSL5,RXFP2,RLN2,RLN3A,INSL3 |
| GPCR ligand binding | OPN1LW,OXGR1,PTHRP2,CGA,CCR9,FFAR3,SSTR4,GPR77,DRD4,CCL27 |
| Peptide ligand-binding receptors | NPSR1,RXFP2,NTS,PENKA,TAC2,CXCR7B,PNOC,QRFPR,CXCL11.8,CCL35.1 |
| G alpha (i) signalling events | POMCB,SSTR3,LPAR2B,SSTR2,GAL,PENK,RLN3A,RGS1,TAS2R13,DRD4 |
| G alpha (s) signalling events | ADM2A,CRH,ADRB3,PTH2,GCGB,ADCYAP1,DRD5,PDE10A,NPSR1,VIP2 |
| Signal Transduction | HHAT,INSL3,TLE4,RHOU,EVC,FSTL1A,RPE65A,IGF2BP1,PMEPA1,RHOUA |
| Class A/1 (Rhodopsin-like receptors) | DRD5,AGT,OXTRL,GPR37L1,CX3CR1,ADORA1,GPR68,CNR2,CCBP2,GPR4 |
Protein Function
RLN3 has several biochemical functions, for example, G-protein coupled receptor binding,hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RLN3 itself. We selected most functions RLN3 had, and list some proteins which have the same functions with RLN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | NPFFL,SFTPB,S1PR2,GNA11B,GNAI2B,ITGB4,ADORA1,STUB1,POMC,QRFP |
| hormone activity | UTS2,PPY,GCGA,PRL5A1,SMTLA,CALCA,LEP,Gh,INSL3,AMH |
| protein binding | OOEP,KLHL2,ADRA2A,BCL2L16,SRSF10,ZNF224,MCM8,PTPN9,CCDC130,GRHL2 |
Interacting Protein
RLN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RLN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RLN3.
RXFP4
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References
- Bitto, A; Irrera, N; et al. Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice. CLINICAL SCIENCE 125:575-585(2013).
- Reitemeier, S; Haense, M; et al. Antibody selection for immunocytochemical characterization of the male reproductive system in Psittaciformes. THERIOGENOLOGY 80:597-608(2013).
