RGS10
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Official Full Name
regulator of G-protein signaling 10 -
Overview
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RGS10;regulator of G-protein signaling 10;regulator of G protein signalling 10;Regulator of G protein signaling 10;RGS10_HUMAN;regulator of G-protein signalling 10
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RGS10 involved in several pathways and played different roles in them. We selected most pathways RGS10 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | OR4D2,GRP,QRFPR,SST,ADORA2A,PROK2,CHRM4,RGS4,NET1,TIAM2 |
| G alpha (i) signalling events | RGS21,PTGDR2,CCR7,CHRM2,SST,OPN5,OXGR1A.3,GAL,APPB,CCL35.1 |
| Myometrial Relaxation and Contraction Pathways | CRHR1,ATF5,CNN2,GABPB1,RGS5,RGS11,RAMP3,RGS16,RXFP2,IGFBP2 |
| Calcium Regulation in the Cardiac Cell | RGS5B,GNB5B,GJA3,CHRM1,GJB6,CX27.5,RGS14,KCNJ5,CX30.3,AKR1C1 |
| Signaling by GPCR | CCL19A.2,PROKR1,PYY,PLEKHG2,GPR31B,GPR37B,FGD4,RGS11,INSL5,TAS2R3 |
| Signal Transduction | RHOV,RPGRIP1L,GPR120,ZFPM2B,FAM13B,IFT88,CLIP3,GREM2,PDE10A,ARHGEF18 |
Protein Function
RGS10 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS10 itself. We selected most functions RGS10 had, and list some proteins which have the same functions with RGS10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | TBC1D2B,ARHGAP23,ARHGAP35,ARHGAP12,RASAL2,CDC42EP4A,EVI5,HTR2B,NF1,DOCK4 |
Interacting Protein
RGS10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS10 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS10.
SAP18;EIF6;ARF6
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References
- Doupnik, CA; Xu, T; et al. Profile of RGS expression in single rat atrial myocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1522:97-107(2001).
- Rivero, G; Gabilondo, AM; et al. Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. NEUROCHEMISTRY INTERNATIONAL 57:722-729(2010).
- Tansey, MG; Goldberg, MS; et al. Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention. NEUROBIOLOGY OF DISEASE 37:510-518(2010).
