RGS1
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Official Full Name
regulator of G-protein signaling 1 -
Overview
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. -
Synonyms
RGS1;regulator of G-protein signaling 1;IER1, regulator of G protein signalling 1;1R20;BL34;IR20;B cell activation protein BL34;B-cell activation protein BL34;Early response protein 1R20;IER 1;IER1;Immediate early response 1B cell specific;Regulator of G protein signalling 1;RGS 1;RGS1_HUMAN;regulator of G-protein signalling 1;immediate-early response 1, B-cell specific
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Mammalian Cell
- E.coli
- HEK293
- His
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
RGS1 involved in several pathways and played different roles in them. We selected most pathways RGS1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | ADM2,PENKB,OXER1,PIK3R6,GPR55,MGLL,CCL35.2,APLN,EDNRAB,ADORA1 |
| G alpha (i) signalling events | LPAR5A,SOUL4,RGS7,APPA,SOUL3,ANXA1A,HRH3,SSTR2,RGS14,DRD4 |
| Class A/1 (Rhodopsin-like receptors) | OPN1SW1,CCL19A.2,DRD2,CNR1,POMCB,TAC1,OXGR1A.1,CCR1,LPAR2A,ADRB3 |
| Signal Transduction | SOX4A,FGFBP2,NOXO1,KLHL12,EMR4,CRABP2,GRB10A,GPR68,NOG1,OPN1LW2 |
| Opsins | OPN5,OPN1LW1,OPN1SW1,RGR,OPN4A,OPN4,OPN1LW2,OPN4.1,OPN4B |
| Signaling by GPCR | VIP,PENK,OPN1SW1,TAC2,EDNRAB,OXGR1A.2,OXGR1A.1,RGS6,RGS17,OPN4A |
| GPCR ligand binding | CNR1,GPR55,PROKR1A,EMR4,GPR39,TAS2R13,GAL,FPR-RS4,KISS1,FZD10 |
Protein Function
RGS1 has several biochemical functions, for example, G-protein coupled receptor activity,photoreceptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS1 itself. We selected most functions RGS1 had, and list some proteins which have the same functions with RGS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| photoreceptor activity | EXORH,OPN1MW1,RGR,VALOPB,RPA1,OPN1SW1,OPN4.1,OPN1SW,TMTOPS3A,RHO |
| protein binding | ZFHX3,CRHR2,ZG16,LMO1,ASL,ELP4,DNMT3L,LRRC33,XRCC3,ERCC8 |
| G-protein coupled receptor activity | OR7C1,OLFR498,EDNRAB,GRM3,GPR3,CASR,DRD1A,GPR157,GPR139,VALOPA |
Interacting Protein
RGS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS1.
LRRK2;MAP3K12;TSC22D1;UTP14A;FUNDC2
Resources
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References
- Koren, E; Zhou, H; et al. Unique Co-expression of Immune Cell-related Genes in IBDV Resistant Chickens Indicates the Activation of Specific Cellular Host-response Mechanisms. ANIMAL GENOMICS FOR ANIMAL HEALTH 132:153-159(2008).
- Koga, H; Imada, K; et al. Identification of differentially expressed molecules in adult T-cell leukemia cells proliferating in vivo. CANCER SCIENCE 95:411-417(2004).
