RFX6

  • Official Full Name

    regulatory factor X, 6

  • Overview

    The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.

  • Synonyms

    RFX6;regulatory factor X, 6;regulatory factor X domain containing 1 , RFXDC1;DNA-binding protein RFX6;dJ955L16.1;MGC33442;DNA binding protein RFX6;Regulatory factor X domain containing protein 1;RFX6 regulatory factor X, 6;regulatory factor X domain-containing protein 1;RFXDC1
Cat.# Product name Source (Host) Species Tag Protein Length Price
RFX6-14117M Recombinant Mouse RFX6 Protein Mammalian Cell Mouse His
RFX6-2395HCL Recombinant Human RFX6 293 Cell Lysate HEK293 Human Non
RFX6-7553M Recombinant Mouse RFX6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RFX6-7553M-B Recombinant Mouse RFX6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RFX6 involved in several pathways and played different roles in them. We selected most pathways RFX6 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Maturity onset diabetes of the young NR5A2,HNF4G,HNF1B,HNF1A,MNX1,INS1,PAX6,HNF4A,ONECUT1,MAFA

    Protein Function

    RFX6 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFX6 itself. We selected most functions RFX6 had, and list some proteins which have the same functions with RFX6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ETV6,PBX1,EP300,NFYC,ELK1,ETV1,RUNX2,AGO1,RFX1A,CRX
    RNA polymerase II regulatory region sequence-specific DNA binding H2AFY,BCL6,GATA5,RARA,CDX1A,ZNF584,ZGLP1,ZBTB16A,ZNF79,HSF2
    protein binding MZT1,PRDX3,EFCAB12,AMFR,RPS25,VPS37A,RC3H2,TIMM8A,FAM125B,TBX22
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding FEZF2,GATA1,MAFB,GLIS1,REST,AIRE,CREB3L3,RXRB,TRPS1,CSRNP3
    transcription regulatory region DNA binding AIRE,TRP53,BASP1,EGR2,MLL1,WNT5A,ZNF613,PRDM5,CTCF,TP53

    Interacting Protein

    RFX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFX6.

    DTX2;VPS37C;FRS3;STK16;SNRPB;PRKAA2;AES

    Resources

    Research Area

    Pancreatic Endoderm Cell Markers
    Pancreatic Progenitor Cell Transcription Factors
    Hepatic and Pancreatic Progenitor Cell Transcription Factors
    Endodermal Lineage Markers

    References

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