RFWD2
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Official Full Name
ring finger and WD repeat domain 2 -
Overview
E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene. RFWD2 has been shown to interact with C-jun. -
Synonyms
RFWD2;ring finger and WD repeat domain 2;E3 ubiquitin-protein ligase RFWD2;COP1;FLJ10416;RNF200;Constitutive photomorphogenesis protein 1 homolog;COP;hCOP1;RFWD2_HUMAN;RING finger and WD repeat domain protein 2;RING finger protein 200;OTTHUMP00000032911;OTTHUMP00000032913;OTTHUMP00000235258;putative ubiquitin ligase COP1;constitutive photomorphogenic protein (COP1);constitutive ph;RP11-318C24.3
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- HEK293
- Mammalian Cell
- E.coli
- Myc&DDK
- His
- His&Fc&Avi
Involved Pathway
RFWD2 involved in several pathways and played different roles in them. We selected most pathways RFWD2 participated on our site, such as p signaling pathway,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFWD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | HERC3,HUWE1,RNF7,SYVN1,BRCA1,AIRE,PPIL2,WWP2,UBE2N,UBE2KA |
| p signaling pathway | RRM2B,COP1,IGFBP3,CCNB2,CCND2A,ATM,STEAP3,TP53AIP1,CD82B,IGF1 |
Protein Function
RFWD2 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RFWD2 itself. We selected most functions RFWD2 had, and list some proteins which have the same functions with RFWD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF11B,PIAS2,RNF111,ISL1L,MMP24,LPP,ZDHHC23,MT2A,BMP1,CCNB1IP1 |
| ligase activity | WWP2,UBR5,HECW1B,UBE3C,RNF19B,NEURL1B,HECTD1,GATB,MKRN2,RNF146 |
| protein-glycine ligase activity, elongating | ZNRF2B,UBE2IA,RAG1,UBE2IB,DTX1,HECW2,RNF180,MYLIPA,MARCH4,LTN1 |
| UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity | SHRPRBCK1R,UBR1,MUL1A,HECW2,RAG1,RNF187,MARCH4,LTN1,MARCH6,G2E3 |
| protein-glycine ligase activity, initiating | SIAH1A,MGRN1A,RAG1,ZNRF3,TMEM129,NEURL3,MARCH11,RC3H2,UBR1,TRIM41 |
| ribosomal S6-glutamic acid ligase activity | LTN1,TRIM71,HECW2,MGRN1A,MARCH11,SHRPRBCK1R,NEURL3,ARIH1L,MARCH4,G2E3 |
| metal ion binding | ATP1A3,EFCAB5,MORC2A,PCGF5B,LHX2A,SLX1B,ZNF177,ZNF213,PPP3CC,CREB5 |
| ubiquitin protein ligase activity | UBE2NB,UBR5,MED21,RNF139,UBR1,ARIH1,FBXL22,HECTD3,UBE3B,C12orf51 |
| tubulin-glycine ligase activity | FLR,MYLIPB,TRIM41,MGRN1A,RNF144AA,SIAH2L,NEURL1B,UBE2IA,MARCH11,ZNRF2B |
Interacting Protein
RFWD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFWD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFWD2.
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References
- Cowley, AW; Moreno, C; et al. Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats. PHYSIOLOGICAL GENOMICS 46:398-410(2014).
- Relogio, A; Thomas, P; et al. Ras-Mediated Deregulation of the Circadian Clock in Cancer. PLOS GENETICS 10:-(2014).
