RFFL
-
Official Full Name
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -
Overview
E3 ubiquitin-protein ligase rififylin is an enzyme that in humans is encoded by the RFFL gene. -
Synonyms
RFFL;ring finger and FYVE-like domain containing E3 ubiquitin protein ligase;ring finger and FYVE like domain containing;E3 ubiquitin-protein ligase rififylin;fring;rififylin;RNF34L;RNF189;RING finger protein 189;caspase regulator CARP2;FYVE-RIN
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFFL-2259H | Recombinant Human RFFL, GST-tagged | E.coli | Human | GST | 1-327aa | |
| RFFL-107H |
Active Recombinant Human RFFL, His-tagged
|
E.coli | Human | His |
|
|
| RFFL-639H |
Active Recombinant Human RFFL Protein, GST-tagged
|
Insect Cell | Human | GST |
|
|
| RFFL-2413C | Recombinant Chicken RFFL | Mammalian Cell | Chicken | His |
|
|
| RFFL-5005R | Recombinant Rat RFFL Protein | Mammalian Cell | Rat | His |
|
|
| RFFL-538HCL | Recombinant Human RFFL lysate | HEK293 | Human | Non |
|
|
| RFFL-1050H | Recombinant Human RFFL Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| RFFL-4664R | Recombinant Rat RFFL Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| RFFL-4664R-B | Recombinant Rat RFFL Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| RFFL-5299H | Recombinant Human RFFL Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| Rffl-5477M | Recombinant Mouse Rffl Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
Involved Pathway
RFFL involved in several pathways and played different roles in them. We selected most pathways RFFL participated on our site, such as TNF receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF receptor signaling pathway | NRK,TNIK,MAP4K5 |
Protein Function
RFFL has several biochemical functions, for example, ligase activity,p53 binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFFL itself. We selected most functions RFFL had, and list some proteins which have the same functions with RFFL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | WASH1,TNFRSF14,RNF31,ATP6V0C,LRPPRC,DNM1L,DNAJA1,FBXW7,UBE2V2,GABARAPL2 |
| ligase activity | MIB2,NEURL3,MARCH9,RNF130,RNF169,RNF220,CBX4,RNF152,PDZRN3,RNF115 |
| ubiquitin protein ligase activity | PRPF19,UBE2C,MED24,CCNB1IP1,RNF25,UBE3C,CDC34,MED7,UBE3B,ANKIB1 |
| zinc ion binding | RBX1,MT1M,CCS,ESR2A,KDM2AA,HLTF,MMP26,PHC2,ZNF330,PAPLN |
| protein binding | SULT2B1,RNASE1,DRAXIN,TAF1B,CYTH1,AP3M1,PFN2,STK10,DYDC1,AGO3 |
| protease binding | XBP1,FLOT2,CHL1,PINK1,DERL1,IL1R1,Cstb,CD70,DVL3,INS2 |
| protein kinase binding | TELO2,AGAP2,TRIM5,MAPK8IP2,CDKN2C,FBXO7,BORA,CACNB3,ATG13,JIP1 |
| p53 binding | ZFP346,GATA1,ZMAT4,KDM1A,ZNF385B,TRP53,SETD7,TAF1,GSK3B,ZNF385A |
Interacting Protein
RFFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFFL here. Most of them are supplied by our site. Hope this information will be useful for your research of RFFL.
CASP8;UBE2G2
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References
- Dong, YJ; Zhao, JH; et al. Tumor Suppressor Functions of miR-133a in Colorectal Cancer. MOLECULAR CANCER RESEARCH 11:1051-1060(2013).
