RFC3
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Official Full Name
replication factor C (activator 1) 3, 38kDa -
Overview
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
RFC3;replication factor C (activator 1) 3, 38kDa;replication factor C (activator 1) 3 (38kD);replication factor C subunit 3;A1 38 kDa subunit;MGC5276;RFC;38 kD subunit;RFC38;Activator 1 38 kDa subunit;Activator 1 subunit 3;HGNC:9971;replication factor C (activator 1) 3;Replication factor C 3;Replication factor C 38 kDa subunit;RFC 38 kD subunit;RFC 38 kDa subunit;OTTHUMP00000018237;RFC, 38 kD subunit;RF-C 38 kDa subunit
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Rhesus macaque
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFC3-11503Z | Recombinant Zebrafish RFC3 | Mammalian Cell | Zebrafish | His |
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| RFC3-1423C | Recombinant Chicken RFC3 | Mammalian Cell | Chicken | His |
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| RFC3-2980H | Recombinant Human RFC3, T7-tagged | E.coli | Human | T7 | 1-356 a.a. |
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| RFC3-3857R | Recombinant Rhesus monkey RFC3 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RFC3-2411HCL | Recombinant Human RFC3 293 Cell Lysate | HEK293 | Human | Non |
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| RFC3-04HFL | Recombinant Full Length Human RFC3 Protein, C-Myc/DDK-tagged | HEK293T | Human | Myc&DDK | Full L. |
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| RFC3-2653H | Recombinant Human RFC3 Protein, His-tagged | E.coli | Human | His | Met1-Pro288 |
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| RFC3-3674R | Recombinant Rhesus Macaque RFC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RFC3-3674R-B | Recombinant Rhesus Macaque RFC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Rfc3-5475M | Recombinant Mouse Rfc3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
RFC3 involved in several pathways and played different roles in them. We selected most pathways RFC3 participated on our site, such as DNA replication,Nucleotide excision repair,Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | YY1A,ERCC6,GTF2H3-2,RAD23AB,ERCC2,POLE2,CCNH,GTF2H2,RAD23A,ERCC3 |
| DNA Replication | DNA2,MCM6,PRIM1,DBF4,MCM3L,PRIM2,MCM6L,PCNA,POLD1,POLD4 |
| Mismatch repair | MSH6,MLH3,RPA4,PCNA,RPA2,RFC5,SSBP1,EXO1,RPA3,MSH3 |
Protein Function
RFC3 has several biochemical functions, for example, contributes_to ATPase activity,contributes_to DNA binding,DNA clamp loader activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RFC3 itself. We selected most functions RFC3 had, and list some proteins which have the same functions with RFC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA clamp loader activity | RAD17 |
| contributes_to DNA binding | MRE11A,GTF3C2,NFE2L2A,GTF3C4,MCM7,MLXIPL,AHR2,MAFGA,ARNTL1A,CLOCKA |
| contributes_to ATPase activity | ATP1A2,ATP5I,SFRP5,PPP2R4,ATP5O,ABCA7,ATP5D,ATP5C1,ATP5F1,RUVBL2 |
| protein binding | USP15,PARD6A,POLR1A,ID2,SKIV2L2,BLOC1S4,DLC1,GATAD2B,BTRC,CRB3 |
Interacting Protein
RFC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFC3.
RFC4;RFC1;RFC2;USP20;PHLDA3;MESDC2;ARFGAP1;Brwd3;ssdna_dtdc
Resources
Related Services
Related Products
References
- Chae, HD; Mitton, B; et al. CREB Regulates Cell Cycle Progression through RFC3-PCNA Axis in Acute Myeloid Leukemia. BLOOD 124:-(2014).
- Hatfield, KJ; Reikvam, H; et al. Identification of a subset of patients with acute myeloid leukemia characterized by long-term in vitro proliferation and altered cell cycle regulation of the leukemic cells. EXPERT OPINION ON THERAPEUTIC TARGETS 18:1237-1251(2014).
