RELN
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Official Full Name
Reelin -
Overview
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for;cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia,;autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations;of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants;encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their;full length nature has not been determined. -
Synonyms
RELN;reelin;RL;LIS2;PRO1598;EC 3.4.21.;OT-THUMP00000211831;OTTHUMP00000211830
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian cells
- Mammalian Cell
- Yeast
- HEK293
- His
- His&T7
- His&S
- His&Fc&Avi
Involved Pathway
RELN involved in several pathways and played different roles in them. We selected most pathways RELN participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RELN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | ITGB1A,ERBB2,DIAPH1,PTK2AA,PRKCBB,TNW,IGF1RA,PIK3R5,MYL7,ITGB1 |
| PIK-Akt signaling pathway | CREB5,IFNA12,Il4ra,SGK3,PPP2R2B,Gh,CCNE2,IFNAR1,FGF14,TNC |
| ECM-receptor interaction | ITGA3B,FN1,LAMC1,COL5A2,ITGB3,LAMA4,ITGA2,Npnt,VWF,ITGA10 |
Protein Function
RELN has several biochemical functions, for example, hydrolase activity,lipoprotein particle receptor binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RELN itself. We selected most functions RELN had, and list some proteins which have the same functions with RELN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| very-low-density lipoprotein particle receptor binding | APOEA,APOEB,PCSK9,APOE,LRPAP1 |
| metal ion binding | BRIP1,SCD5,ZFP473,HGS,FYCO1,NRXN2B,LIAS,KCNIP1B,ZFP12,ZFP551 |
| peptidase activity | TMPRSS11D,PSMB9B,CTSM,AGA,FOLH1,MPND,Casp3,ELANE,MBTPS2,C6AST1 |
| serine-type peptidase activity | OVCH2,TMPRSS11B,KLK1B11,PRSS41,PARLA,ST14A,HPN,GZMC,PLG,PRSS40 |
| hydrolase activity | DHX32A,GZMC,OVCH2,DPEP3,MMP25,LYZ1,PGCP,PA2G4B,Amy1,HRASLS |
| lipoprotein particle receptor binding | LRP1,APOA5 |
| protein binding | APOOL,MAPK11,HEBP2,PICALM,ABCD2,GLMN,EGLN1,IFT88,PINX1,ANKMY2 |
Interacting Protein
RELN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RELN here. Most of them are supplied by our site. Hope this information will be useful for your research of RELN.
Resources
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References
- Ramirez, AEG; Martinez, AD; et al. Epigenetics and twin studies in psychiatric domains. SALUD MENTAL 31:229-237(2008).
- Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
