RCC2
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Official Full Name
regulator of chromosome condensation 2 -
Overview
RCC2/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors. RCC2/TD-60 is associated with the chromosome passenger complex (CPC), which also consists of aurora B kinase, borealin, INCENP (inne -
Synonyms
RCC2;regulator of chromosome condensation 2;protein RCC2;TD 60;RCC1-like protein TD-60;telophase disk protein of 60 kDa;TD-60;KIAA1470;DKFZp762N0610
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RCC2-2230H | Recombinant Human RCC2, His-tagged | E.coli | Human | His | 168-522aa | |
| RCC2-12390Z | Recombinant Zebrafish RCC2 | Mammalian Cell | Zebrafish | His |
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| RCC2-14032M | Recombinant Mouse RCC2 Protein | Mammalian Cell | Mouse | His |
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| RCC2-7496M | Recombinant Mouse RCC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RCC2-7496M-B | Recombinant Mouse RCC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RCC2 involved in several pathways and played different roles in them. We selected most pathways RCC2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPase Effectors | ABI1B,SPC24,RANGAP1B,SPDL1,NUF2,NF2A,WASF3,KTN1,CLIP1,NOXA1 |
| Mitotic Metaphase and Anaphase | ZWILCH,SKA1,SPDL1,SKA2,TMPO,SGOL1,PDS5B,ANKLE2,DSN1,NUDC |
| Mitotic Anaphase | WAPAL,AHCTF1,NDEL1,SKA2,SGOL1,SPDL1,PDS5A,SPC24,ITGB3BP,INCENP |
| M Phase | CENPH,SMC2,DSN1,NDEL1B,KIF2B,SETA,ENSAB,WAPAL,CENPQ,NUDC |
| Cell cycle | CENPJ,YWHAQ,CSNK2B,CKAP5,TUBB4A,WAPAL,GMNN,CENPK,MDM2,B9D2 |
| Cell Cycle, Mitotic | CEP290,CEP135,CSNK2B,NCAPD2,GINS4,SPDL1,CEP152,SDCCAG8,GMNN,MLF1IP |
| RHO GTPases Activate Formins | CLIP1,CCDC99,FMNL2,NUF2,SKA1,EVL,NSL1,KNTC1,ZWINT,SKA2 |
| Mitotic Prometaphase | WAPAL,MLF1IP,SGOL1,CDCA5,SMC2,SPC25,DSN1,CENPK,SPDL1,PANE1 |
Protein Function
RCC2 has several biochemical functions, for example, Rac GTPase binding,microtubule binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCC2 itself. We selected most functions RCC2 had, and list some proteins which have the same functions with RCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | PLCG1,KIF13B,PPP1CC,ZC3HC1,AXIN1,MAPT,GATA6,NEK6,AGAP2,NEFH |
| small GTPase binding | ERRFI1,FGD4,PEX5,FGD1,ABCA1,FGD5,FGD2,GDI2,FGD6,FLNA |
| microtubule binding | KIF17,DPYSL5B,ZNF207,GCAP14,CCDC87,NDEL1,CASC1,ARL3,KIF5A,CEP350 |
| protein binding | ARFIP2,ARHGAP1,UIMC1,WIPF1,DAPK2,C2orf50,ATE1,ATP2B4,RAB3C,CTNNA3 |
| Rac GTPase binding | RALBP1,PAK7,ARHGEF2,PAK2A,SRGAP3,PAK1,SRGAP1,PAK4,SRGAP2B,HACE1 |
| protein domain specific binding | HPCAL4,VCP,YWHAQA,CASKIN1,HIST1H4N,CEP68,NEDD4,ANGEL1,AKAP1,VAPA |
| poly(A) RNA binding | RPL13,ZC3H7A,HOXB6,HNRNPK,CNOT4,DCAF13,DUSP11,RPL21,ZNF622,NME1 |
Interacting Protein
RCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCC2.
HLA-B;VHL;EIF6;ARF6;ATG5;FTSJ1;TNIK;PRKAB1;TRAF6;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;AIM2;FN1;VCAM1;Nedd1;HDGF
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References
- Grigera, PR; Ma, L; et al. Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. JOURNAL OF PROTEOMICS 75:2153-2159(2012).
- Yang, F; Camp, DG; et al. Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus. JOURNAL OF CELL SCIENCE 120:4060-4070(2007).
- Kishimoto, K; Nishizawa, Y; et al. Detailed analysis of rice chitinase gene expression in transgenic cucumber plants showing different levels of disease resistance to gray mold (Botrytis cinerea). PLANT SCIENCE 162:655-662(2002).
