RBL1

  • Official Full Name

    retinoblastoma-like 1 (p107)

  • Overview

    The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RBL1;retinoblastoma-like 1 (p107);retinoblastoma-like protein 1;cp107;p107;PRB1;cellular protein 107;107 kDa retinoblastoma-associated protein;MGC40006
Cat.# Product name Source (Host) Species Tag Protein Length Price
RBL1-2204H Recombinant Human RBL1, GST-tagged E.coli Human GST 1-351aa
RBL1-7092Z Recombinant Zebrafish RBL1 Mammalian Cells Zebrafish His
RBL1-2484HCL Recombinant Human RBL1 293 Cell Lysate HEK293 Human Non
RBL1-067H Recombinant Human RBL1 Protein E.coli Human 1068

    Involved Pathway

    RBL1 involved in several pathways and played different roles in them. We selected most pathways RBL1 participated on our site, such as Cell cycle,TGF-beta signaling pathway,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle MND1,CP110,CDC7,DSN1,ORC6L,MAPRE1B,UIMC1,SUN1,MLF1IP,PDS5A
    Viral carcinogenesis TRAF2,HIST1H4I,SYK,UBE3A,NFKBIA,VAC14,PIK3R1,SND1,HDAC9,EGR3
    TGF-beta signaling pathway CHRD,BMP8A,LEFTY2,BAMBIB,INHBAB,SMAD3,FSTA,SMAD4,EP300,ZFYVE16

    Protein Function

    RBL1 has several biochemical functions, for example, protein binding,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBL1 itself. We selected most functions RBL1 had, and list some proteins which have the same functions with RBL1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FANCG,TMEM25,RAB1A,SHFM1,SENP3,ZNF18,BCL2L16,TUBA3E,CD79A,SUV420H2
    transcription factor binding APBB1,SRY,SUMO1,JUNBA,NLK,MYBBP1A,NKX3-1,PPP1R13BB,ESRRB,CREG1

    Interacting Protein

    RBL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBL1.

    CDK2;E7;DHX30;e1a_ade05;DYRK1A;DYRK1B;E7

    Resources

    Research Area

    CKIs(Cyclin Dependent Kinase Inhibitors)

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All RBL1 Products

    Required fields are marked with *

    My Review for All RBL1 Products

    Required fields are marked with *