RBFOX3
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Official Full Name
RNA binding protein, fox-1 homolog (C. elegans) 3 -
Overview
NeuN (RNA binding protein fox-1 homolog 3; Fox-1 homolog C) is a RNA-binding protein found exclusively in the nuclei of neuronal cells. It is a member of the evolutionarily conserved Fox-1 family and is mainly involved in splicing of RNA. -
Synonyms
RBFOX3;RNA binding protein, fox-1 homolog (C. elegans) 3;RNA binding protein fox-1 homolog 3;fox-1 homolog C;neuronal nuclei;neuronal nuclear antigen A60;hexaribonucleotide binding protein 3;NeuN;Fox-3;Hrnbp3;Neuna60;D11Bwg0517e;RP23-159O6.5
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- E. coli
- HEK293
- His
- GST
- N-GST & C-His
- His&Myc
- His&Fc&Avi
Involved Pathway
RBFOX3 involved in several pathways and played different roles in them. We selected most pathways RBFOX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RBFOX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RBFOX3 has several biochemical functions, for example, DNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBFOX3 itself. We selected most functions RBFOX3 had, and list some proteins which have the same functions with RBFOX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | FOXN2B,NR4A2B,UPF1,ZBTB43,WBP7,ZNF711,FOXQ2,NKX6.3,PHTF1,C17orf49 |
| mRNA binding | TSN,NXF3,DHFRL1,NANOS2,QKI,RBMY1A1,CPSF5,TRA2B,QK,DCP1B |
| nucleotide binding | PDPK1A,RBM17,ATP2B3B,RAB14L,DQX1,CKBB,ATP8A1,ACTA1A,POLD1,DHX36 |
Interacting Protein
RBFOX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBFOX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBFOX3.
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References
- Lucas, CH; Calvez, M; et al. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). NEUROSCIENCE LETTERS 558:97-102(2014).
- Maxeiner, S; Glassmann, A; et al. The molecular basis of the specificity and cross-reactivity of the NeuN epitope of the neuron-specific splicing regulator, Rbfox3. HISTOCHEMISTRY AND CELL BIOLOGY 141:43-55(2014).
- Kim, KK; Nam, J; et al. Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. JOURNAL OF CELL BIOLOGY 200:443-458(2013).
- Dredge, BK; Jensen, KB; et al. NeuN/Rbfox3 Nuclear and Cytoplasmic Isoforms Differentially Regulate Alternative Splicing and Nonsense-Mediated Decay of Rbfox2. PLOS ONE 6:-(2011).
