RASSF8
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Official Full Name
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -
Overview
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is;essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration.;It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion;of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced;transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RASSF8;Ras association (RalGDS/AF-6) domain family (N-terminal) member 8;C12orf2, chromosome 12 open reading frame 2;ras association domain-containing protein 8;HoJ 1;carcinoma-associated protein HOJ-1;HOJ1;C12orf2;FLJ11542;DKFZp434O0227
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RASSF8 involved in several pathways and played different roles in them. We selected most pathways RASSF8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RASSF8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF8 itself. We selected most functions RASSF8 had, and list some proteins which have the same functions with RASSF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
RASSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF8.
YWHAG;YWHAH;TP53BP2;Klc1;KDM1A;PSMD4;FRMD6;POLR2H;TCOF1;PARP10;ANKRD28;PPP1CC;YAP1;Yap1;RAB5C
RASSF8 Related Signal Pathway
Resources
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References
- McMahon, GM; Olden, M; et al. Sequencing of LRP2 Reveals Multiple Rare Variants Associated with Urinary Trefoil Factor-3. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:2896-2905(2014).
- Lang, YG; Xu, SD; et al. MicroRNA-429 induces tumorigenesis of human non-small cell lung cancer cells and targets multiple tumor suppressor genes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450:154-159(2014).
