RASSF1
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Official Full Name
Ras association (RalGDS/AF-6) domain family member 1 -
Overview
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. -
Synonyms
RASSF1;Ras association (RalGDS/AF-6) domain family member 1;ras association domain-containing protein 1;123F2;NORE2A;RDA32;REH3P21;Ras association domain containing protein 1;Ras association domain family 1;Ras association domain family protein 1;RASF1_HUMAN;RASSF 1a;RASSF1A;RASSF1A isoform;Tumor suppressor protein RDA32;WUGSC:H_LUCA12.5;OTTHUMP00000195503;OTTHUMP00000195504;OTTHUMP00000195505;OTTHUMP00000195507;cardiac-specific ras association domain family 1 protein;pancreas-specific ras associat
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RASSF1-1274Z | Recombinant Zebrafish RASSF1 | Mammalian Cells | Zebrafish | His |
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| RASSF1-376H | Recombinant Human Ras association (RalGDS/AF-6) domain family member 1, His-tagged | E.coli | Human | His | 1-340 a.a. |
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| RASSF1-740H | Recombinant Human RASSF1 | Mammalian Cells | Human | His |
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| RASSF1-2499HCL | Recombinant Human RASSF1 293 Cell Lysate | HEK293 | Human | Non |
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| RASSF1-3967H | Recombinant Human RASSF1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| RASSF1-3967H-B | Recombinant Human RASSF1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
RASSF1 involved in several pathways and played different roles in them. We selected most pathways RASSF1 participated on our site, such as Bladder cancer,Hippo signaling pathway,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p53 pathway | TTC5,KAT8,CSE1L,DYRK2,TRIM28,PPP1R13L,HUWE1,CSNK1G3,E4F1,FBXO11 |
| MicroRNAs in cancer | ABL1,EZH2,MMP9,ZEB1,Abcb1b,VEGFA,NRAS,PRKCE,PTEN,MAP2K1 |
| Hippo signaling pathway | NF2,FZD5,BMPR1A,TP73,BIRC2,WNT7B,PARD3,PPP2R2C,LEF1,TGFBR1 |
| Pathways in cancer | HHIP,STAT1,RASGRP3,MET,CDC42,AKT1,PRKCA,PTGER2,WNT4,WNT3 |
| Non-small cell lung cancer | PIK3CB,PIK3CG,RARB,RASSF5,GRB2,PLCG2,PIK3R2,FOXO3,PIK3R5,ARAF |
| Ras signaling pathway | FGFR3,GNG10,INSR,PRKACG,NGF,IKBKG,IGF1,RAC2,MAPK1,PDGFRA |
| Bladder cancer | MMP1,KRAS,FGFR3,MAPK1,TRP53,RB1,CCND1,E2F3,THBS1,NRAS |
Protein Function
RASSF1 has several biochemical functions, for example, identical protein binding,protein N-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF1 itself. We selected most functions RASSF1 had, and list some proteins which have the same functions with RASSF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PPARD,UBE2L3,ZBTB4,CDCP1,ESRP1,MAP4,C4orf33,RNF165,DLG1,HJURP |
| zinc ion binding | ZSWIM3,RXRB,RXRBA,ZFYVE20,MMP1,SPG7,CA8,BTR02,PXN,PGLYRP2 |
| identical protein binding | STIM1,DCTPP1,POLG2,STAC3,SFRP1,SH3GL2,CLDN23,ADORA2A,KDM6A,TMEM115 |
| protein N-terminus binding | ACTN4,MECP2,MAU2,NIPBL,TSC1,GTF2H3,TDRD7,TRAF6,APTX,NPAT |
Interacting Protein
RASSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF1.
STK4;STK3;DAXX;SUV39H2
RASSF1 Related Signal Pathway
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