RASGRP4
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Official Full Name
RAS guanyl releasing protein 4 -
Overview
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RASGRP4;RAS guanyl releasing protein 4;RAS guanyl-releasing protein 4;guanyl nucleotide releasing protein 4
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
RASGRP4-2191H | Recombinant Human RASGRP4, GST-tagged | E.coli | Human | GST | 1-168aa | |
RASGRP4-13955M | Recombinant Mouse RASGRP4 Protein | Mammalian Cell | Mouse | His | ||
RASGRP4-3983Z | Recombinant Zebrafish RASGRP4 | Mammalian Cell | Zebrafish | His | ||
RASGRP4-4938R | Recombinant Rat RASGRP4 Protein | Mammalian Cell | Rat | His | ||
RASGRP4-1477HCL | Recombinant Human RASGRP4 cell lysate | Human | Non | |||
RASGRP4-4597R | Recombinant Rat RASGRP4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi | ||
RASGRP4-4597R-B | Recombinant Rat RASGRP4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat | |||
RASGRP4-7439M | Recombinant Mouse RASGRP4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi | ||
RASGRP4-7439M-B | Recombinant Mouse RASGRP4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
Involved Pathway
RASGRP4 involved in several pathways and played different roles in them. We selected most pathways RASGRP4 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Developmental Biology | LGI4,CEBPB,TCF3B,PTPRA,MED9,EFNB2A,TRIO,FGF8B,COL4A3,MYF6 |
Cytokine Signaling in Immune system | SPTA1,CISH,WDR83,IL17RD,ISG20,CSHL1,KPNA4,CSF2,IRAK3,HBEGF |
DAP12 signaling | KLB,LAMTOR2,NEFLB,JAK1,NRG2A,THEM4,SPNA1,HBEGF,CSF2RA,PAQR3B |
Downstream signaling of activated FGFR1 | CNKSR1,SPTA1,PHB,DUSP2,RASGEF1A,SPRED2,MARK3,SPNA1,SPTB,DUSP9 |
Downstream signal transduction | SPRED2,FGF18B,MOV10,SPRED3,SPNA1,JAK1,PTPRA,THEM4,PAQR3B,KBTBD7 |
DAP12 interactions | FRS2,PAQR3A,JAK1,DUSP7,SPRED2,PTPRA,TREM1,SPTBN1,KBTBD7,CSF2RA |
Axon guidance | EPHB2,EPHA8,DUSP2,AP2M1,SCN4A,PAK2,ROCK1,DPYSL4,NRG2A,COL9A3 |
ARMS-mediated activation | NETO2,KIDINS220B,FGF20A,JAK3,DUSP7,SPTB,DUSP9,PSMD14,PSMD9,PTPRA |
Protein Function
RASGRP4 has several biochemical functions, for example, GTP-dependent protein binding,Ras guanyl-nucleotide exchange factor activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP4 itself. We selected most functions RASGRP4 had, and list some proteins which have the same functions with RASGRP4. You can find most of the proteins on our site.
Function | Related Protein |
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Ras guanyl-nucleotide exchange factor activity | ADRB1,RAPGEF5,RASGEF1B,SOS1,RASGEF1BB,RASGRP3,RASGEF1BA,RAPGEF4,KNDC1,RAB3A |
GTP-dependent protein binding | PPIAL4A,CDC42,GCHFR,RAB32,GCH1,EEA1,AP3B1,AP1G1,RAB5B,RAPGEF5 |
diacylglycerol binding | RASGRP1,TRPC2,UNC13A,RASGRP3,RASGRP2,UNC13C,UNC13B,CDIPT |
calcium ion binding | KCNIP4,MMP13,CHP2,DSG1,SYT5B,FKBP10,CIB4,ADAM8,CAPN2A,CDK5R1 |
Interacting Protein
RASGRP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP4.
RAP1A
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