RASGRP3

  • Official Full Name

    RAS guanyl releasing protein 3 (calcium and DAG-regulated)

  • Overview

    Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).

  • Synonyms

    RASGRP3;RAS guanyl releasing protein 3 (calcium and DAG-regulated);ras guanyl-releasing protein 3;GRP3;KIAA0846;guanine nucleotide exchange factor for Rap1;calcium and DAG-regulated guanine nucleotide exchange factor III

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • GST
  • His
  • His&GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
RASGRP3-2190H Recombinant Human RASGRP3, GST-tagged E.coli Human GST C-term-349aa
RASGRP3-1543C Recombinant Chicken RASGRP3 Mammalian Cell Chicken His
RASGRP3-3794R Recombinant Rhesus monkey RASGRP3 Protein, His-tagged Mammalian Cell Rhesus macaque His
RASGRP3-405H Recombinant Human RASGRP3 Protein, GST/His-tagged E.coli Human His&GST
RASGRP3-6184Z Recombinant Zebrafish RASGRP3 Mammalian Cell Zebrafish His
RASGRP3-2504HCL Recombinant Human RASGRP3 293 Cell Lysate HEK293 Human Non
RASGRP3-3611R Recombinant Rhesus Macaque RASGRP3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
RASGRP3-3611R-B Recombinant Rhesus Macaque RASGRP3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Rasgrp3-5391M Recombinant Mouse Rasgrp3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    RASGRP3 involved in several pathways and played different roles in them. We selected most pathways RASGRP3 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway DDIT3,KRAS,HSPA1L,PTPN7,MAP4K2,ARRB2,ECSIT,MAP3K6,HSPA1A,HSPA2
    Pathways in cancer MMP1A,BIRC7,CASP9,BDKRB1,RASSF1,GNG13,TRP53,TRAF1,CTBP2,NFKBIA
    Ras signaling pathway ELK1,PGF,SOS1,GNG11,RAC1,EFNA4,INSR,NRAS,GNGT2,PRKACA
    Rap signaling pathway FGF11,RAPGEF5,CDC42,MAP2K2,PIK3CG,PLCG1,PIK3R5,Pdgfa&Pdgfb,KITLG,FGF21
    B Cell Receptor Signaling Pathway FOS,RELA,CDK4,CR2,BCL10,PILRB,ARPC1B,PIK3AP1,GSK3B,IFITM1

    Protein Function

    RASGRP3 has several biochemical functions, for example, GTPase activator activity,Ras GTPase binding,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP3 itself. We selected most functions RASGRP3 had, and list some proteins which have the same functions with RASGRP3. You can find most of the proteins on our site.

    Function Related Protein
    kinase binding GFAP,CHIA,CTNNB1,LDHB,STUB1,PER3,CHP1,SLC2A1,SRC,HPCA
    guanyl-nucleotide exchange factor activity PLCE1,NET1,ARHGEF7A,RAPGEF6,RASGEF1BA,DOCK11,RALGPS2,RPGR,RINL,TRIO
    Ras guanyl-nucleotide exchange factor activity RAPGEF5,SOS1,RAPGEF4,RAB3A,RASGEF1BB,RASGEF1B,RASGRP1,RASGEF1A,RGL2,KNDC1
    Ras GTPase binding MAP2K1,RAPGEF6,SH3BP4,CIB1,MLLT4,RGL3,RAP1GAP,MAPKAP1,SPHK2,RAPGEF4
    signal transducer activity HTR2CL1,BAI2,LSP1,VMN2R116,OLFR498,IL10RA,GNG12A,OLFR154,GPR161,VMN1R40
    diacylglycerol binding RASGRP2,UNC13B,RASGRP1,CDIPT,UNC13A,UNC13C,RASGRP4,TRPC2
    calcium ion binding SNED1,PPP3CB,SPNA1,PCDHGA5,NCAN,JAG1B,MBL1,SCIN,CDHR1A,SYT1
    GTPase activator activity EVI5L,TBC1D24,ASAP2A,TBC1D2,ARHGEF1,AGFG2,RGS4,TBC1D2B,ARHGAP42A,ARHGAP18
    protein binding CCL11,MYH8,CDC45,C16orf45,SPTAN1,NDP,BAG6,ZWINT,NMRK1,GBP5

    Interacting Protein

    RASGRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP3.

    DYNLL2;YWHAQ;SULT1C2;uxuA

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