RASGEF1A
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Official Full Name
RasGEF domain family, member 1A -
Synonyms
RASGEF1A;RasGEF domain family, member 1A;ras-GEF domain-containing family member 1A;CG4853;FLJ37817;CG4853 gene product
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RASGEF1A-2188H | Recombinant Human RASGEF1A, His-tagged | E.coli | Human | His | 132-481aa | |
| RASGEF1A-2507HCL | Recombinant Human RASGEF1A 293 Cell Lysate | HEK293 | Human | Non |
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| RASGEF1A-1858H | Recombinant Human RASGEF1A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RASGEF1A-1858H-B | Recombinant Human RASGEF1A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| RASGEF1A-2193HFL | Recombinant Full Length Human RASGEF1A Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| Rasgef1a-5385M | Recombinant Mouse Rasgef1a Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RASGEF1A-5596H | Recombinant Human RASGEF1A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
RASGEF1A involved in several pathways and played different roles in them. We selected most pathways RASGEF1A participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGEF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | AGO3,PHB,SPRED1,HBEGF,TRAT1,MARK3,CNKSR1,DUSP4,CSF2RB,FGF18B |
| Downstream signal transduction | SPTBN2,SPRED3,SPTB,TRAT1,AGO2,MARK3,PEA15,KBTBD7,FGF10B,AGO3 |
| DAP12 interactions | HBEGF,WDR83,SPNA2,DUSP2,SPRED2,DUSP4,FGF20A,MARK3,PHB,AGO1 |
| Axon guidance | COL6A3,SEMA4D,PAQR3A,PLXNA1,NFATC3,EFNA5,FRS2B,SCN8A,DPYSL2B,SRGAP2 |
| Downstream signaling of activated FGFR1 | PAQR3A,RASGRP4,SPRED1,AGO2,DUSP2,DUSP9,SPRED3,CNKSR1,IL17RD,SPTA1 |
| ARMS-mediated activation | HBEGF,DUSP7,SPRED1,FRS2,NRG2A,FGF10B,CSF2,FGFR1B,IL17RD,DUSP9 |
| Cytokine Signaling in Immune system | CSH1,IL1RN,EIF4E,SOCS3A,CSK,DUSP9,IRF9,CRK,ARIH1,OASL |
| Developmental Biology | CLTB,LGI2,SCN9A,CDH4,MED10,KIF4A,CACNG2,COL9A3,TRPC3,EFNA4 |
Protein Function
RASGEF1A has several biochemical functions, for example, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGEF1A itself. We selected most functions RASGEF1A had, and list some proteins which have the same functions with RASGEF1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ras guanyl-nucleotide exchange factor activity | RASGEF1BB,RASGRP4,SOS1,RASGEF1BA,RAPGEF5,ADRB1,RASGEF1B,RAPGEF4,RGL2,RASGRP3 |
Interacting Protein
RASGEF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGEF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGEF1A.
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References
- Kim, JH; Cheong, HS; et al. A Genome-Wide Association Study Identifies Potential Susceptibility Loci for Hirschsprung Disease. PLOS ONE 9:-(2014).
- Fernandez, RM; Bleda, M; et al. Four new loci associations discovered by pathway-based and network analyses of the genome-wide variability profile of Hirschsprung's disease. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
