RASA4
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Official Full Name
RAS p21 protein activator 4 -
Overview
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RASA4;RAS p21 protein activator 4;ras GTPase-activating protein 4;CAPRI;GAPL;KIAA0538;Ca2+ promoted Ras inactivator;Calcium promoted Ras inactivator;GTPase activating protein like;MGC131890;Ras GTPase activating protein 4;Ca2+-promoted Ras inactivator;calcium-promoted Ras inactivator;rasGAP-activating-like protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RASA4-13942M | Recombinant Mouse RASA4 Protein | Mammalian Cell | Mouse | His |
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| RASA4-5508C | Recombinant Chicken RASA4 | Mammalian Cell | Chicken | His |
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| RASA4-5777Z | Recombinant Zebrafish RASA4 | Mammalian Cell | Zebrafish | His |
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| RASA4-7429M | Recombinant Mouse RASA4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RASA4-7429M-B | Recombinant Mouse RASA4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RASA4 involved in several pathways and played different roles in them. We selected most pathways RASA4 participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GNG2,PIK3R2,PLA2G2F,EFNA4,ANGPT4,PAK7,GAB1,HRAS,GRIN1,PDGFRB |
Protein Function
RASA4 has several biochemical functions, for example, GTPase activator activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASA4 itself. We selected most functions RASA4 had, and list some proteins which have the same functions with RASA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TRIM35-34,FTR54,ZMYND10,DSG1A,GGTA1,NR2F1A,BCL11AB,PFAS,LMX1BB,NDUFS1 |
| GTPase activator activity | TBC1D30,RGS13,ARHGAP8,ARHGAP33,TBC1D14,RINL,ARHGAP29,RABGAP1,RAP1GDS1,ARHGAP24 |
Interacting Protein
RASA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASA4.
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