RASA3
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Official Full Name
RAS p21 protein activator 3 -
Overview
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. -
Synonyms
RASA3;RAS p21 protein activator 3;ras GTPase-activating protein 3;GAP1IP4BP;GAPIII;GAP III;GAP1(IP4BP);GTPase activating protein III;Inositol 1 3 4 5 tetrakisphosphate binding protein;Inositol 1345 tetrakisphosphate binding protein;Ins P4 binding protein;Ins(1 3 4 5)P4 binding protein;Ins(1345)P4 binding protein;MGC46517;MGC47588;Ras GTPase activating protein 3;RASA 3;OTTHUMP00000018781;ins P4-binding protein;Ins(1,3,4,5)P4-binding protein;inositol 1,3,4,5-tetrakisphosphate-binding protein
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RASA3 involved in several pathways and played different roles in them. We selected most pathways RASA3 participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | INS2,KSR2,AKT2,MAPK10,ABL2,ETS1,FGF14,GRIN2A,GNG5,RASAL1 |
Protein Function
RASA3 has several biochemical functions, for example, GTPase activator activity,calcium-release channel activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASA3 itself. We selected most functions RASA3 had, and list some proteins which have the same functions with RASA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | IMPDH2,DZIP1,ZFP184,ZNF559,STAMBP,ZNF354B,ROCK1,ZNF582,DPYDB,PRUNE |
| calcium-release channel activity | RYR1,RYR3,TRPV1,JPH2,JPH3,RYR2 |
| GTPase activator activity | NF1,USP6NL,ALS2CL,ARHGAP31,VPS9D1,ARHGAP29,FAM13A,RABEP1,DLC1,SGSM2 |
Interacting Protein
RASA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASA3.
Mbd2
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