RAPGEF5
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 5 -
Overview
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)). -
Synonyms
RAPGEF5;Rap guanine nucleotide exchange factor (GEF) 5;rap guanine nucleotide exchange factor 5;MR-GEF;M-Ras-regulated Rap GEF;guanine nucleotide exchange factor;Mrgef;rMR-GEF;RGD1562891
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAPGEF5-3789R | Recombinant Rhesus monkey RAPGEF5 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| RAPGEF5-4928R | Recombinant Rat RAPGEF5 Protein | Mammalian Cells | Rat | His |
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| RAPGEF5-1469HCL | Recombinant Human RAPGEF5 cell lysate | Human | Non |
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| RAPGEF5-3606R | Recombinant Rhesus Macaque RAPGEF5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RAPGEF5-3606R-B | Recombinant Rhesus Macaque RAPGEF5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RAPGEF5-4587R | Recombinant Rat RAPGEF5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RAPGEF5-4587R-B | Recombinant Rat RAPGEF5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
RAPGEF5 involved in several pathways and played different roles in them. We selected most pathways RAPGEF5 participated on our site, such as Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | FGFR1,KLK1B4,SHC1,GNGT1,NGFR,RALB,MRAS,KRAS,GNG8,PLA2G4D |
| Rap signaling pathway | FIGF,FLT4,GRIN2B,PRKD2,NGFR,MAGI1,CDH1,ITGA2B,ANGPT4,CDC42 |
Protein Function
RAPGEF5 has several biochemical functions, for example, GTP-dependent protein binding,Rap guanyl-nucleotide exchange factor activity,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF5 itself. We selected most functions RAPGEF5 had, and list some proteins which have the same functions with RAPGEF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rap guanyl-nucleotide exchange factor activity | RAP1A,RAPGEF3 |
| Ras guanyl-nucleotide exchange factor activity | KNDC1,RASGEF1BA,RASGEF1BB,RASGEF1B,ADRB1,RAPGEF4,RASGRP1,RASGRP3,RASGRP4,RASGEF1A |
| GTP-dependent protein binding | CDC42,RASGRP4,HPS6,EEA1,PARD6A,PPIAL4A,MRAS,AP3B1,ARFIP2,GCHFR |
Interacting Protein
RAPGEF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF5.
TMEM253;PLAC9;VANGL1
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References
- Penzes, P; Woolfrey, KM; et al. Epac2-mediated dendritic spine remodeling: Implications for disease. MOLECULAR AND CELLULAR NEUROSCIENCE 46:368-380(2011).
- Idevall-Hagren, O; Jakobsson, I; et al. Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells. SCIENCE SIGNALING 6:-(2013).
