RAPGEF2
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 2 -
Overview
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)). -
Synonyms
RAPGEF2;Rap guanine nucleotide exchange factor (GEF) 2;PDZ domain containing guanine nucleotide exchange factor (GEF) 1 , PDZGEF1;rap guanine nucleotide exchange factor 2;DKFZP586O1422;KIAA0313;PDZ GEF1;RA GEF;Rap GEP;Neural RAP guanine nucleotide exchange protein;nRap GEP;NRAPGEP;PDZ domain containing guanine nucleotide exchange factor 1;PDZ domain-containing guanine nucleotide exchange factor 1;PDZ-GEF1;PDZGEF1;RA-GEF;RPGF2_HUMAN;OTTHUMP00000220255;RA(Ras/Rap1A-associating)-GEF;PDZ domain containing guanine nucleotide exchange factor (G;Rap-GEP;CNrasGEF
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| RAPGEF2-4926R | Recombinant Rat RAPGEF2 Protein | Mammalian Cell | Rat | His |
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| RAPGEF2-4585R | Recombinant Rat RAPGEF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RAPGEF2-4585R-B | Recombinant Rat RAPGEF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
RAPGEF2 involved in several pathways and played different roles in them. We selected most pathways RAPGEF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
RAPGEF2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF2 itself. We selected most functions RAPGEF2 had, and list some proteins which have the same functions with RAPGEF2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
RAPGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF2.
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References
- Brown, LM; Rogers, KE; et al. Identification and Validation of Modulators of Exchange Protein Activated by cAMP (Epac) Activity. JOURNAL OF BIOLOGICAL CHEMISTRY 289:8217-8230(2014).
- Srivastava, DP; Woolfrey, K; et al. An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice. PLOS BIOLOGY 10:-(2012).
