RAPGEF1
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 1 -
Overview
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. -
Synonyms
RAPGEF1;Rap guanine nucleotide exchange factor (GEF) 1;GRF2, guanine nucleotide releasing factor 2 (specific for crk proto oncogene);rap guanine nucleotide exchange factor 1;C3G;CRK SH3-binding GNRP;guanine nucleotide-releasing factor 2 (specific f
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAPGEF1-2180H | Recombinant Human RAPGEF1, His-tagged | E.coli | Human | His | 748-1095aa | |
| RAPGEF1-2522HCL | Recombinant Human RAPGEF1 293 Cell Lysate | HEK293 | Human | Non |
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| RAPGEF1-5829H | Recombinant Human RAPGEF1 Protein (Lys780-Asn1035), N-His tagged | E.coli | Human | His | Lys780-Asn1035 |
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Involved Pathway
RAPGEF1 involved in several pathways and played different roles in them. We selected most pathways RAPGEF1 participated on our site, such as Rap signaling pathway,Focal adhesion,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | AKT2,PIK3R2,PPP1R3C,PRKAG2,MAPK10,SOCS3B,PRKACAB,PHKA2,SHC1,PRKAR1AB |
| Focal adhesion | ROCK1,TNN,AASS,VCL,PIK3R3A,MAPK8,SHC4,THBS1,LAMC3,VAV3 |
| Renal cell carcinoma | RAC1,RAF1,PIK3CB,EGLN2,RAP1B,PIK3R5,GRB2,FH1,AHA-1,TCEB2 |
| Neurotrophin signaling pathway | NGF,AKT1,ARHGDIB,BCL2,PIK3R5,Fasl,CALML3,ATF4,CALM2,CAMK2G |
| Rap signaling pathway | FIGF,ANGPT1,PRKCI,RASGRP3,FGFR2,ITGB2L,PLCB4,MRAS,ITGB2,PARD6B |
Protein Function
RAPGEF1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF1 itself. We selected most functions RAPGEF1 had, and list some proteins which have the same functions with RAPGEF1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
RAPGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF1.
CRK;ABL1;GRB2;CRKL;FYN;SRC;NCK1
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