RAMP3

  • Official Full Name

    receptor (G protein-coupled) activity modifying protein 3

  • Overview

    The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.

  • Synonyms

    RAMP3;receptor (G protein-coupled) activity modifying protein 3;receptor (calcitonin) activity modifying protein 3 , receptor activity modifying protein 3;receptor activity-modifying protein 3;Calcitonin receptor like receptor activity modifying protein 3;CRLR activity modifying protein 3;Receptor activity modifying protein 3;OTTHUMP00000159549;OTTHUMP00000214279;OTTHUMP00000214280;CRLR activity-modifying protein 3;receptor-activity-modifying protein 3;receptor (calcitonin) activity modifying protein 3

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cell
  • Human Cell
  • HEK293
  • E.coli expression system
  • GST
  • His
  • Non
  • Fc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAMP3-2172H Recombinant Full Length Human RAMP3 Protein, GST-tagged E.coli Human GST Full L. 1-148aa
RAMP3-13907M Recombinant Mouse RAMP3 Protein Mammalian Cell Mouse His
RAMP3-3779R Recombinant Rhesus monkey RAMP3 Protein, His-tagged Mammalian Cell Rhesus macaque His
RAMP3-3906C Recombinant Chicken RAMP3 Mammalian Cell Chicken His
RAMP3-4921R Recombinant Rat RAMP3 Protein Mammalian Cell Rat His
RAMP3-7526H Recombinant Human RAMP3, His-tagged E.coli Human His 24-118aa
RAMP3-8607H Recombinant Human RAMP3, Fc tagged Human Cell Human His 1-118 a.a.
RAMP3-1214HCL Recombinant Human RAMP3 cell lysate Human Cell Human Non
RAMP3-1343H Recombinant Human RAMP3 protein(Met1-Val118), hFc-tagged HEK293 Human Fc Met1-Val118
RAMP3-3596R Recombinant Rhesus Macaque RAMP3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
RAMP3-3596R-B Recombinant Rhesus Macaque RAMP3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RAMP3-4580R Recombinant Rat RAMP3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
RAMP3-4580R-B Recombinant Rat RAMP3 Protein Pre-coupled Magnetic Beads HEK293 Rat
RAMP3-7410M Recombinant Mouse RAMP3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RAMP3-7410M-B Recombinant Mouse RAMP3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL25419HF Recombinant Full Length Human Receptor Activity-Modifying Protein 3(Ramp3) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (24-148)

    Involved Pathway

    RAMP3 involved in several pathways and played different roles in them. We selected most pathways RAMP3 participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Myometrial Relaxation and Contraction Pathways GUCA2B,CRH,IGFBP6,MYLK2,CNN1,GUCA2A,GABPA,RGS5,RGS11,RGS20
    GPCR ligand binding EDN2,INSL3,CCR1,TAC2,XK,GPR132,LTB4R,ADORA2B,PMCH,OPN4.1
    G alpha (s) signalling events ADM,INSL3,CALCRL,RLN2,PTH2,NPSR1,CRHR2,PTHLHA,PTH,ADCYAP1
    Class B/2 (Secretin family receptors) GNB3B,EMR4,SETD6,EMR2,EMR1,GHRH,CRHR2,CALCRL,GNB5A,RAMP2
    Signal Transduction NOG,ARAP2,FSTL1B,TAS2R13,TAAR1,PDK3,DCLRE1B,MYO9B,NMU,EMR3
    Calcitonin-like ligand receptors ADM2,ADM,RAMP2,CALCA,RAMP1,CALCB,CALCRL,ADM2A
    GPCR downstream signaling PENKA,AMCF-II,EDN1,ADORA2A,PTHRP2,ADORA3,CALCA,CHRM5,ARHGEF18A,OPN1MW2
    Signaling by GPCR PPY,CD97,NET1,OXGR1A.1,OPN5,ARHGAP4,ADCYAP1B,RGS12,EMR3,RGS7

    Protein Function

    RAMP3 has several biochemical functions, for example, coreceptor activity,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP3 itself. We selected most functions RAMP3 had, and list some proteins which have the same functions with RAMP3. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity KIR2DL1,CXCR3,CD226,GABRA5,APLNR,GRIA3B,ERBB3B,ADIPOR1B,IGSF1,SEC63
    protein transporter activity KPNA4,IPO4,IPO13,ITGB1BP1,FRAG1,IPO8,RAMP2,RAP1A,AP4B1,TIMM10
    coreceptor activity CCR8,ACVR2A,RAMP1,CD28,ACKR3B,TGFBR3,CD8B,CD80,CCR5,CD8A
    protein binding MAZ,AAGAB,EHD1,GAST,PSMC3,TNFRSF11A,DAB1,ERBB4,NOP58,ATXN1L

    Interacting Protein

    RAMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP3.

    KRTAP5-9;NOTCH2NL;HSPB3;PDCD6IP

    Resources

    References

    • Desai, AJ; Roberts, DJ; et al. Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line. PLOS ONE 9:-(2014).
    • Berenguer-Daize, C; Boudouresque, F; et al. Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice. CLINICAL CANCER RESEARCH 19:6138-6150(2013).

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