RAMP1
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Official Full Name
receptor (G protein-coupled) activity modifying protein 1 -
Overview
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. -
Synonyms
RAMP1;receptor (G protein-coupled) activity modifying protein 1;receptor (calcitonin) activity modifying protein 1 , receptor activity modifying protein 1;receptor activity-modifying protein 1;calcitonin receptor like receptor activity modifying protein 1;CRLR activity modifying protein 1;receptor (G protein coupled) activity modifying protein 1;receptor activity modifying protein 1 [Precursor];CRLR activity-modifying protein 1;receptor activity modifying protein 1;receptor (calcitonin) activity modifying protein 1;calcitonin receptor-like receptor activity modifying protein 1;calcitonin-receptor-like receptor activity-modifying protein 1
Recombinant Proteins
- Human
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAMP1-421H | Recombinant Human receptor (G protein-coupled) activity modifying protein 1, His-tagged | E.coli | Human | His | 27-117 a.a. |
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| RAMP1-4919R | Recombinant Rat RAMP1 Protein | Mammalian Cell | Rat | His |
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| RAMP1-5022H | Recombinant Human RAMP1, His-tagged | E.coli | Human | His |
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| RAMP1-742H | Recombinant Human RAMP1 | Mammalian Cell | Human | His |
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| RAMP1-2537HCL | Recombinant Human RAMP1 293 Cell Lysate | HEK293 | Human | Non |
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| RAMP1-3965H | Recombinant Human RAMP1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| RAMP1-3965H-B | Recombinant Human RAMP1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| RAMP1-4578R | Recombinant Rat RAMP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RAMP1-4578R-B | Recombinant Rat RAMP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL4296HF | Recombinant Full Length Human Receptor Activity-Modifying Protein 1(Ramp1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (27-148) |
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Involved Pathway
RAMP1 involved in several pathways and played different roles in them. We selected most pathways RAMP1 participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class B/2 (Secretin family receptors) | PTH,ADM,GHRH,GNB3A,CRHB,ADCYAP1B,EMR1,RAMP3,CRH,EMR2 |
| Endothelin | CNN1,ECE1,CALCRL,CALCA,MYL1,EDNRB,EDNRA,EDN1 |
| Myometrial Relaxation and Contraction Pathways | RGS7,RGS10,PKIB,ADM,RGS4,RAMP2,PKIG,CNN2,ATF5,CNN1 |
| G alpha (s) signalling events | TAAR1,GCGA,ADM2A,RXFP2,RLN3,DRD5,VIP,RLN3A,PTHLH,CGA |
| GPCR ligand binding | FPR-RS4,PNOC,GPR65,CNR1,HRH3,ADM2A,CCK,RAMP3,CALCA,FPR-RS3 |
| GPCR downstream signaling | APLNR,QRFPR,TAS2R16,CCR9,RGS1,EDNRAB,TAC3,ADORA2A,ARHGAP4A,ADORA3 |
| Signal Transduction | PYYA,SOX4B,RDH10,GREM2,CRABP1B,AMOTL2A,PNOCB,LINGO1,TJP2B,RLN1 |
| Calcitonin-like ligand receptors | ADM2,CALCA,ADM,ADM2A,CALCRL,RAMP2,RAMP3,CALCB |
Protein Function
RAMP1 has several biochemical functions, for example, calcitonin receptor activity,calcitonin receptor binding,coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP1 itself. We selected most functions RAMP1 had, and list some proteins which have the same functions with RAMP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | KIR2DL3,CADM2,P2RY11,VMN1R48,FKBP3,NPR2,APLNR,VMN1R46,P2RY1,RET |
| protein binding | C6orf211,CASQ2,C19orf80,IL23,ADCK3,RORA,CLASP1,HNRNPF,KRT33B,MFAP4 |
| protein transporter activity | TIMM9,TNPO1,RAP1A,AP1S3B,ARFGAP3,RAB4A,DSCR3,CALCRL,IPO13,KPNA7 |
| calcitonin receptor binding | CALCA |
| coreceptor activity | CXCR4,ZP2,ACKR3B,TGFBR3,HFE2,CCR8,TMIGD2,LY96,RAMP3,CD8B |
| calcitonin receptor activity | CALCRLA,CALCR,CALCRL |
Interacting Protein
RAMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP1.
CALCRL
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References
- Desai, AJ; Roberts, DJ; et al. Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line. PLOS ONE 9:-(2014).
- Seiler, K; Nusser, JI; et al. Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment. JOURNAL OF HEADACHE AND PAIN 14:-(2013).
Reviews
Q&As
Many thanks for your interest in our products. This protein will be produced upon order. You can decide the sequence of this Fc tag.