RAD51L1
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Official Full Name
RAD51-like 1 (S. cerevisiae) -
Overview
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. -
Synonyms
RAD51L1;RAD51-like 1 (S. cerevisiae);DNA repair protein RAD51 homolog 2;RAD51 homolog B;RAD51-like protein 1;R51H2;mREC2;Rad51b;AI553500
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAD51L1-13873M | Recombinant Mouse RAD51L1 Protein | Mammalian Cell | Mouse | His |
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| RAD51L1-7388M | Recombinant Mouse RAD51L1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RAD51L1-7388M-B | Recombinant Mouse RAD51L1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RAD51L1 involved in several pathways and played different roles in them. We selected most pathways RAD51L1 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | XRCC2,RAD51,TOP3A,MRE11A,POLD1,RAD51D,TOP3B,CDK5R2,RPA2,BRCA2 |
Protein Function
RAD51L1 has several biochemical functions, for example, ATP binding,DNA binding,DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51L1 itself. We selected most functions RAD51L1 had, and list some proteins which have the same functions with RAD51L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| recombinase activity | XRCC2,RAD51C,RAD51,XRCC3,RAD51L3,DMC1,RAD51B,RBPJ,RAD51D |
| single-stranded DNA binding | LUZP4,CSDA,PURB,CNBPA,CDC45,SSBP4,NME2,LRPPRC,PEO1,TTC6 |
| DNA binding | TBPL2,ARID3C,FLYWCH1,ZFP92,SOX21,TGIF2LX,LHX8,C14orf43,ZFP775,RPS3 |
| double-stranded DNA binding | AFF3,TP53,HMGB1,PRKDC,FEN1,USF1,CRY1,CTNNB1,ZNF638,TP63 |
| DNA-dependent ATPase activity | RAD51L3,MSH4,CDK7,CHD8,DDX11,IGHMBP2,SMARCAL1,CHD6,MSH2,TOP2A |
| four-way junction DNA binding | HMGB3,RAD51,HMGB1,YY1,DMC1,HMGB2,RAD51L3,MEN1 |
| ATP binding | SIK3,RPS6KA3,PTK2BB,MAP3K6,TRPV1,PIP4K2C,TOR1L3,SRPK1A,CDK2,BUB1B |
| contributes_to four-way junction DNA binding | RAD51L3,RAD51B,RAD51D,RAD51C,MSH2,MSH6,XRCC3,XRCC2 |
| nucleotide binding | ABCG2D,SSB,RBM41,BMPR1BA,ZCRB1,RBPMS,TIA1,SAR1AB,SEPT9A,POLDIP3 |
Interacting Protein
RAD51L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51L1.
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References
- Joshi, AD; Lindstrom, S; et al. Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium. AMERICAN JOURNAL OF EPIDEMIOLOGY 180:1018-1027(2014).
- Yoshida, H; Miyachi, M; et al. Identification of COL3A1 and RAB2A as Novel Translocation Partner Genes of PLAG1 in Lipoblastoma. GENES CHROMOSOMES & CANCER 53:606-611(2014).
