RABGEF1
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Official Full Name
RAB guanine nucleotide exchange factor (GEF) 1 -
Overview
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] -
Synonyms
RABGEF1;RAB guanine nucleotide exchange factor (GEF) 1;RAP1;RABEX5;rabex-5;rab5 GDP/GTP exchange factor;rabaptin-5-associated exchange factor for Rab5
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RABGEF1-2142H | Recombinant Human RABGEF1, His-tagged | E.coli | Human | His | C-term-358aa | |
| RABGEF1-11096Z | Recombinant Zebrafish RABGEF1 | Mammalian Cell | Zebrafish | His |
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| RABGEF1-13849M | Recombinant Mouse RABGEF1 Protein | Mammalian Cell | Mouse | His |
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| RABGEF1-2575HCL | Recombinant Human RABGEF1 293 Cell Lysate | HEK293 | Human | Non |
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| RABGEF1-1149H | Recombinant Human RABGEF1 Protein (1-491 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-491 aa |
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| Rabgef1-5339M | Recombinant Mouse Rabgef1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RABGEF1-7372M | Recombinant Mouse RABGEF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RABGEF1-7372M-B | Recombinant Mouse RABGEF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RABGEF1 involved in several pathways and played different roles in them. We selected most pathways RABGEF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RABGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RABGEF1 has several biochemical functions, for example, DNA binding,Rab GTPase binding,Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RABGEF1 itself. We selected most functions RABGEF1 had, and list some proteins which have the same functions with RABGEF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | ZCCHC2,DNPEP,PGLYRP3,PCGF5B,MORC4,RNF121,TRIM105,PGLYRP1,LMO1,APOBEC4 |
| protein binding | USP17L2,MR1,TTC25,HSPA4L,SNRPE,NUDT18,KARS,PIFO,SNRPB,NR4A3 |
| DNA binding | HIST1H4K,TFAP2C,KLF9,POLA1,CERS2,MLL1,RBPJA,ZFP746,TOP2A,GZF1 |
| ubiquitin protein ligase activity | SIAH2,UBE2C,ARIH1,HECTD1,SIAH1A,UHRF2,RNF7,AKTIP,UBR5,FANCF |
| Rab guanyl-nucleotide exchange factor activity | ST5,PRSS56,ALS2,DENND1B,DENND3,DENND1A,DENND4B,DENND2A,FAM116A,DENND1C |
| Rab GTPase binding | RHOBTB3,STXBP5A,RAB11FIP4,RGP1,HPS6,RABGAP1L,SYTL3,BICD1,SGSM3,TBC1D7 |
Interacting Protein
RABGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RABGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RABGEF1.
UBB;EGFR;YWHAB;YWHAG;TEAD4;UBC
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