RAB11FIP2
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Official Full Name
RAB11 family interacting protein 2 (class I) -
Overview
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. -
Synonyms
RAB11FIP2;RAB11 family interacting protein 2 (class I);nRip11;Rab11-FIP2;rab11 family-interacting protein 2;RAB11-FIP2 long isoform
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAB11FIP2-394H | Recombinant Human RAB11FIP2 Protein, His-tagged | E.coli | Human | His |
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| RAB11FIP2-2629HCL | Recombinant Human RAB11FIP2 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
RAB11FIP2 involved in several pathways and played different roles in them. We selected most pathways RAB11FIP2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB11FIP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SNX5,GBF1,ASAP2B,FMNL3,ARPC1B,MDM2,PARD6A,HSPA1B,TGFBR1B,ARF6A |
Protein Function
RAB11FIP2 has several biochemical functions, for example, Rab GTPase binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB11FIP2 itself. We selected most functions RAB11FIP2 had, and list some proteins which have the same functions with RAB11FIP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DKC1,ASF1A,NFYB,VPS29,C5orf13,AGGF1,BIN2,IL7,RAC1,PDCD1 |
| protein kinase binding | MAPKAP1,CRY1,FGF19,MAPK6,RB1CC1,MSH2,PTPN2,ZFP36,NEFH,IBTK |
| protein homodimerization activity | GPD1A,CCBL1,MCL1B,PRPS1,TIMM10,LRRK2,TRIM5,HSP90AA1,BAK1,IDE |
| Rab GTPase binding | BICD1,PIFO,RHOBTB3,RAB11FIP5,NSF,ATP6AP1,EVI5,HACE1,ODF2,TMEM127 |
Interacting Protein
RAB11FIP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB11FIP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB11FIP2.
RAB11A;YWHAG;LRRK2;Myo5b;Tubgcp6;Naa15;ATP6AP2;AK1;GJB2;YWHAB;CLCN2;JAK3;Rab11a;YWHAZ;YWHAH;KLC1;KIF7
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References
- Kelly, EE; Horgan, CP; et al. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. BIOLOGY OF THE CELL 102:51-62(2010).
- Horgan, CP; McCaffrey, MW; et al. The dynamic Rab11-FIPs. BIOCHEMICAL SOCIETY TRANSACTIONS 37:1032-1036(2009).
