RAB11A
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Official Full Name
RAB11A, member RAS oncogene family -
Overview
Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes. Despite some overlap, dis -
Synonyms
RAB11A;RAB11A, member RAS oncogene family;ras-related protein Rab-11A;YL8;rab-11;RAB 11A, member oncogene family;MGC1490
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
RAB11A involved in several pathways and played different roles in them. We selected most pathways RAB11A participated on our site, such as Endocytosis,Endocrine and other factor-regulated calcium reabsorption,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | IQSEC3,WIPF1A,PRKCZ,PIP5K1A,SMURF1,CLTCA,GIT2A,FAM125B,SH3GLB2A,BF2 |
| Pancreatic secretion | ATP1B4,PLCB1,GNAS,TPCN2,PLCB3,ATP1A4,CD38,BST1,ATP1A1,KCNMA1 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B11,PRKACG,KLK1,DNM3,KLK1B1,ATP1B1,KLK1B24,KLK1B22,BDKRB2,KLK2 |
Protein Function
RAB11A has several biochemical functions, for example, GTP binding,GTPase activity,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB11A itself. We selected most functions RAB11A had, and list some proteins which have the same functions with RAB11A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | TUBB2,TPX2,SEPT5A,TUBB6,HBS1L,TUBD1,GIMAP2,MB21D1,NOA1,ACSM1 |
| syntaxin binding | STX10,SYTL1,STX8,SNAP23.2,SYT17,TMED9,STX7,SYT13,SYT7,CPLX3B |
| GTPase activity | RAB4B,TUBA3C,RAB10,TUBAL3,SEPT5,RAB43,RALBA,TUBB4A,IRGE4,RNF112 |
| myosin V binding | RAB6B,RAB39B,RAB6A,RAB27A,RAB25,RAB3B,RAB14,FUS,RAB8A,RAB11B |
| protein binding | ADAMTSL3,TBC1D20,FTSJ3,SCGB2A2,CIZ1,RFESD,DAB2,IREB2,ZMYM2,C16orf72 |
| microtubule binding | DPYSL2,CAMSAP1A,DPYSL5A,MAST2,NDEL1B,APC2,SPAG8,PAFAH1B1A,KIF18A,KIFC3 |
Interacting Protein
RAB11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB11A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB11A.
RAB11FIP2;ZFYVE27;RAB11FIP1;RAB11FIP5;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;RAB11FIP3;GRB2;PIK3R3;RAB3IP
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References
- Watanuki, Z; Kosai, H; et al. Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 455:269-276(2014).
- Gui, AP; Kobayashi, A; et al. Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells. BMC CANCER 12:-(2012).
